Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AR | P10275 | 4/20 | 0.48 |
| ▸ | DRD2 | P14416 | 2/20 | 0.43 |
| ▸ | DRD3 | P35462 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | CNR1 | P21554 | 1/20 | 0.40 |
| ▸ | CNR2 | P34972 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.38 |
| ▸ | MAOA | P21397 | 2/20 | 0.38 |
| ▸ | MAOB | P27338 | 2/20 | 0.38 |
| ▸ | TSHR | P16473 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14034630 | 0.95 | AR (0.52) | ARDRD2DRD3SMN1; SMN2KDM4E | |
| SCHEMBL18724536 | 0.81 | SIRT2 (0.45) | DRD2DRD3SMN1; SMN2HSD17B10L3MBTL1 | |
| SCHEMBL3925562 | 0.80 | PTGS2 (0.49) | ARSMN1; SMN2ALDH1A1CNR2HSD17B10 | |
| SCHEMBL5694453 | 0.80 | KDM4E (0.56) | ARSMN1; SMN2KDM4ENPC1ALDH1A1 | |
| SCHEMBL10019245 | 0.78 | MAPK1 (0.41) | SMN1; SMN2HSD17B10L3MBTL1MAPK1MAOA | |
| SCHEMBL2979985 | 0.78 | KDM4E (0.54) | ARSMN1; SMN2KDM4ENPC1ALDH1A1 | |
| SCHEMBL7846740 | 0.78 | KDM4E (0.54) | ARSMN1; SMN2KDM4ENPC1ALDH1A1 | |
| SCHEMBL10019244 | 0.78 | MAPK1 (0.44) | SMN1; SMN2HSD17B10L3MBTL1MAPK1MAOA | |
| SCHEMBL8386311 | 0.78 | KDM4E (0.54) | ARSMN1; SMN2KDM4ENPC1ALDH1A1 | |
| SCHEMBL7835337 | 0.78 | KDM4E (0.54) | ARSMN1; SMN2KDM4ENPC1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1824479-B1 | PHENYLPIPERAZINE DERIVATIVES WITH A COMBINATION OF PARTIAL DOPAMINE-D2 RECEPTOR AGONISM AND SEROTONIN REUPTAKE INHIBITION | SOLVAY PHARM BV (NL) | 2008-11-05 | — | — | EP | disclosed |
| EP-1827427-B1 | ARYLOXYETHYLAMINE DERIVATIVES WITH A COMBINATION OF PARTIAL DOPAMINE-D2 RECEPTOR AGONISM AND SEROTONIN REUPTAKE INHIBITION | SOLVAY PHARM BV (NL) | 2008-07-23 | — | — | EP | disclosed |