Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 5/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.41 |
| ▸ | NPC1 | O15118 | 3/20 | 0.41 |
| ▸ | EGLN1 | Q9GZT9 | 2/20 | 0.40 |
| ▸ | RAB9A | P51151 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.35 |
| ▸ | PPARG | P37231 | 1/20 | 0.35 |
| ▸ | NCOA2 | Q15596 | 1/20 | 0.35 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2497612 | 0.88 | EGLN1 (0.53) | MEN1KMT2ANPC1EGLN1HIF1A | |
| SCHEMBL14034821 | 0.82 | EGLN1 (0.41) | MEN1KMT2AEGLN1RAB9AALDH1A1 | |
| SCHEMBL14034820 | 0.80 | CYP1A2 (0.41) | MEN1KMT2AEGLN1ALDH1A1MAPT | |
| SCHEMBL12217688 | 0.80 | MEN1 (0.46) | MEN1KMT2ANPC1EGLN1RAB9A | |
| SCHEMBL2495407 | 0.72 | EGLN1 (0.53) | MEN1KMT2AEGLN1HIF1A | |
| SCHEMBL14034926 | 0.71 | KMT2A (0.45) | MEN1KMT2ANPC1EGLN1RAB9A | |
| SCHEMBL2499300 | 0.70 | EGLN1 (0.53) | MEN1KMT2ANPC1EGLN1HIF1A | |
| SCHEMBL2497860 | 0.69 | EGLN1 (0.57) | EGLN1ALDH1A1HIF1AKDM4E | |
| SCHEMBL14034795 | 0.69 | EGLN1 (0.72) | MEN1KMT2ANPC1EGLN1RAB9A | |
| SCHEMBL2498913 | 0.68 | EGLN1 (0.50) | EGLN1ALDH1A1HIF1AKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008137060-A1 | THIENOPYRIDINE AND THIAZOLOPYRIDINE DERIVATIVES THAT INHIBIT PROLYL HYDROXYLASE ACTIVITY | AMGEN INC. (US) | 2008-11-13 | — | — | WO | disclosed |