Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 3/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.41 |
| ▸ | MEN1 | O00255 | 4/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
| ▸ | EGLN1 | Q9GZT9 | 3/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | ATM | Q13315 | 1/20 | 0.36 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.36 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.36 |
| ▸ | CLK1 | P49759 | 1/20 | 0.35 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.35 |
| ▸ | GFER | P55789 | 1/20 | 0.35 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2498913 | 0.88 | EGLN1 (0.50) | CYP1A2CYP3A4KDM4ELMNAEGLN1 | |
| SCHEMBL14034821 | 0.81 | EGLN1 (0.41) | CYP1A2CYP3A4MEN1KMT2ACYP2C9 | |
| SCHEMBL14034819 | 0.80 | MEN1 (0.41) | MEN1KMT2AKDM4EEGLN1ALDH1A1 | |
| SCHEMBL10084715 | 0.79 | MEN1 (0.42) | MEN1KMT2AKDM4EHTTLMNA | |
| SCHEMBL2495407 | 0.71 | EGLN1 (0.53) | MEN1KMT2AEGLN1 | |
| SCHEMBL2582113 | 0.69 | EGLN1 (0.55) | EGLN1 | |
| SCHEMBL2497860 | 0.69 | EGLN1 (0.57) | KDM4EEGLN1ALDH1A1 | |
| SCHEMBL10085744 | 0.69 | NPC1 (0.42) | MEN1KMT2AKDM4EHTTLMNA | |
| SCHEMBL14034926 | 0.68 | KMT2A (0.45) | MEN1KMT2AKDM4EHTTEGLN1 | |
| SCHEMBL10084718 | 0.68 | MEN1 (0.45) | MEN1KMT2AKDM4EHTTEGLN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008137060-A1 | THIENOPYRIDINE AND THIAZOLOPYRIDINE DERIVATIVES THAT INHIBIT PROLYL HYDROXYLASE ACTIVITY | AMGEN INC. (US) | 2008-11-13 | — | — | WO | disclosed |