Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAK | O14976 | 13/20 | 0.54 |
| ▸ | RIPK2 | O43353 | 11/20 | 0.54 |
| ▸ | COQ8A | Q8NI60 | 10/20 | 0.54 |
| ▸ | NLK | Q9UBE8 | 10/20 | 0.54 |
| ▸ | KDR | P35968 | 1/20 | 0.52 |
| ▸ | RAF1 | P04049 | 1/20 | 0.49 |
| ▸ | BRAF | P15056 | 1/20 | 0.49 |
| ▸ | EPHB6 | O15197 | 3/20 | 0.47 |
| ▸ | ABL1 | P00519 | 3/20 | 0.47 |
| ▸ | ACVR1 | Q04771 | 2/20 | 0.47 |
| ▸ | STK16 | O75716 | 1/20 | 0.47 |
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.46 |
| ▸ | LCK | P06239 | 2/20 | 0.45 |
| ▸ | EPHA1 | P21709 | 2/20 | 0.45 |
| ▸ | EPHA8 | P29322 | 2/20 | 0.45 |
| ▸ | EGFR | P00533 | 2/20 | 0.45 |
| ▸ | BMPR1B | O00238 | 1/20 | 0.45 |
| ▸ | SRC | P12931 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14035048 | 0.87 | RIPK2 (0.56) | GAKRIPK2COQ8ANLKKDR | |
| SCHEMBL30880714 | 0.86 | GAK (0.65) | GAKRIPK2COQ8ANLKKDR | |
| SCHEMBL30880678 | 0.86 | GAK (0.65) | GAKRIPK2COQ8ANLKKDR | |
| SCHEMBL30880470 | 0.86 | GAK (0.65) | GAKRIPK2COQ8ANLKKDR | |
| SCHEMBL2289246 | 0.86 | GAK (0.65) | GAKRIPK2COQ8ANLKKDR | |
| Hydrochloric Acid SCHEMBL2291538 | 0.85 | GAK (0.64) | GAKRIPK2COQ8ANLKKDR | |
| SCHEMBL30880543 | 0.84 | HTT (0.66) | GAKRIPK2COQ8ANLKKDR | |
| SCHEMBL13768243 | 0.81 | GAK (0.58) | GAKRIPK2COQ8ANLKKDR | |
| SCHEMBL2285466 | 0.79 | GAK (0.48) | GAKRIPK2COQ8ANLKKDR | |
| SCHEMBL12414419 | 0.79 | GAK (0.47) | GAKRIPK2COQ8ANLKKDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008141843-A1 | NOVEL SULPHOXIMINE-SUBSTITUTED QUINAZOLINE AND QUINAZOLINE DERIVATIVES AS KINASE INHIBITORS | BAYER SCHERING PHARMA AKTIENGESELLSCHAFT (DE) | 2008-11-27 | — | — | WO | disclosed |