Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 2/20 | 0.38 |
| ▸ | NNMT | P40261 | 3/20 | 0.33 |
| ▸ | BRD4 | O60885 | 1/20 | 0.32 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.31 |
| ▸ | GDA | Q9Y2T3 | 1/20 | 0.31 |
| ▸ | MGMT | P16455 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
| ▸ | GAA | P10253 | 1/20 | 0.30 |
| ▸ | HPGD | P15428 | 1/20 | 0.30 |
| ▸ | RAB9A | P51151 | 1/20 | 0.30 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4639102 | 0.79 | PARP1 (0.43) | PARP1NNMTBRD4PDPK1GDA | |
| SCHEMBL4638920 | 0.73 | KMT2A (0.42) | PARP1RAB9A | |
| SCHEMBL4638871 | 0.72 | PARP1 (0.38) | PARP1NNMTPDPK1GDA | |
| SCHEMBL14337344 | 0.72 | PARP1 (0.38) | PARP1NNMTPDPK1GDA | |
| SCHEMBL14035177 | 0.70 | PARP1 (0.43) | PARP1NNMTBRD4PDPK1GDA | |
| SCHEMBL14348180 | 0.69 | PARP1 (0.53) | PARP1NNMTPDPK1GDAKDM4E | |
| SCHEMBL29579061 | 0.69 | BRD4 (0.40) | PARP1NNMTBRD4KDM4EGAA | |
| SCHEMBL4640230 | 0.67 | KDM4E (0.45) | PARP1PDPK1KDM4ERAB9A | |
| SCHEMBL14347857 | 0.66 | PARP1 (0.49) | PARP1NNMTPDPK1GDA | |
| SCHEMBL7366515 | 0.66 | PARP1 (0.45) | PARP1NNMTBRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1594862-B1 | METHODS OF MAKING 6-[ (4,5-DIHYDRO-1H-IMIDAZOL-2-YL)AMINO-] -7-METHYL-1H-BENZIMIDAZOLE-4-CARBONITRILE AND ITS PREFERRED SALT FORM | UNIV NEBRASKA (US) | 2008-11-19 | — | — | EP | disclosed |