Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 3/20 | 0.53 |
| ▸ | CASP6 | P55212 | 1/20 | 0.49 |
| ▸ | TPMT | P51580 | 1/20 | 0.48 |
| ▸ | HCAR3 | P49019 | 6/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | APEX1 | P27695 | 1/20 | 0.42 |
| ▸ | CES2 | O00748 | 1/20 | 0.41 |
| ▸ | CES1 | P23141 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL503451 | 0.84 | TSHR (0.65) | TSHRCASP6TPMTHCAR3LMNA | |
| SCHEMBL3582465 | 0.80 | TSHR (0.64) | TSHRCASP6TPMTHCAR3LMNA | |
| SCHEMBL2903129 | 0.78 | TPMT (0.64) | TSHRCASP6TPMTHCAR3LMNA | |
| SCHEMBL2902973 | 0.77 | LMNA (0.60) | TSHRCASP6TPMTHCAR3LMNA | |
| SCHEMBL450228 | 0.77 | TSHR (0.56) | TSHRCASP6TPMTHCAR3LMNA | |
| SCHEMBL23699540 | 0.77 | TSHR (0.56) | TSHRCASP6TPMTHCAR3LMNA | |
| SCHEMBL30858307 | 0.77 | TSHR (0.56) | TSHRCASP6TPMTHCAR3LMNA | |
| SCHEMBL2671570 | 0.77 | TSHR (0.56) | TSHRCASP6TPMTHCAR3LMNA | |
| SCHEMBL2894998 | 0.77 | TSHR (0.56) | TSHRCASP6TPMTHCAR3LMNA | |
| SCHEMBL2720816 | 0.77 | TSHR (0.56) | TSHRCASP6TPMTHCAR3LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1594862-B1 | METHODS OF MAKING 6-[ (4,5-DIHYDRO-1H-IMIDAZOL-2-YL)AMINO-] -7-METHYL-1H-BENZIMIDAZOLE-4-CARBONITRILE AND ITS PREFERRED SALT FORM | UNIV NEBRASKA (US) | 2008-11-19 | — | — | EP | disclosed |