Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPM5 | Q9NZQ8 | 1/20 | 0.59 |
| ▸ | CDC7 | O00311 | 1/20 | 0.52 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.48 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.46 |
| ▸ | MAOB | P27338 | 3/20 | 0.46 |
| ▸ | MAOA | P21397 | 2/20 | 0.46 |
| ▸ | ACHE | P22303 | 1/20 | 0.46 |
| ▸ | SYK | P43405 | 2/20 | 0.43 |
| ▸ | CTNNB1 | P35222 | 1/20 | 0.43 |
| ▸ | TCF7 | P36402 | 1/20 | 0.43 |
| ▸ | TGFBR1 | P36897 | 2/20 | 0.42 |
| ▸ | VNN1 | O95497 | 1/20 | 0.41 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13996634 | 0.88 | CYP1A2 (0.47) | TRPM5CDC7NOTUMCYP1A2GRM4 | |
| SCHEMBL13106720 | 0.83 | TRPM5 (0.53) | TRPM5CDC7NOTUMNPC1ALDH1A1 | |
| SCHEMBL8311439 | 0.82 | CDC7 (0.55) | TRPM5CDC7NOTUMNPC1ALDH1A1 | |
| SCHEMBL30279147 | 0.82 | CDC7 (0.55) | TRPM5CDC7NOTUMNPC1ALDH1A1 | |
| SCHEMBL16406933 | 0.82 | TRPM5 (0.56) | TRPM5CDC7NOTUMNPC1ALDH1A1 | |
| SCHEMBL13106705 | 0.82 | TRPM5 (0.56) | TRPM5CDC7NOTUMNPC1ALDH1A1 | |
| SCHEMBL13993990 | 0.81 | CDC7 (0.51) | TRPM5CDC7NOTUMNPC1ALDH1A1 | |
| SCHEMBL20369249 | 0.81 | CDC7 (0.54) | TRPM5CDC7NOTUMNPC1ALDH1A1 | |
| SCHEMBL3274399 | 0.81 | CDC7 (0.57) | TRPM5CDC7NOTUMNPC1ALDH1A1 | |
| SCHEMBL13106733 | 0.80 | TRPM5 (0.53) | TRPM5CDC7NOTUMNPC1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230109839-A1 | THERAPEUTIC AGENT FOR TAUOPATHIES | Sumitomo Pharma Co., Ltd. (JP) | 2023-04-13 | — | — | US | disclosed |
| EP-3828174-A1 | PYRIDAZINONE DERIVATIVE | Sumitomo Dainippon Pharma Co., Ltd. (JP) | 2021-06-02 | — | — | EP | disclosed |
| EP-2464228-B1 | SUBSTITUTED CYCLOPROPYL COMPOUNDS, COMPOSITIONS CONTAINING SUCH COMPOUNDS AND METHODS OF TREATMENT | MERCK SHARP & DOHME (US) | 2017-12-06 | — | — | EP | disclosed |
| US-7446195-B2 | High affinity thiophene-based and furan-based kinase ligands | SCHERING CORPORATION (US) | 2008-11-04 | — | — | US | disclosed |
| US-20070043045-A1 | Novel high affinity thiophene-based and furan-based kinase ligands | SCHERING CORPORATION | 2007-02-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230109839-A1 | THERAPEUTIC AGENT FOR TAUOPATHIES | MAPT, PSEN1, PSEN2 | TRPM5 37/4885CDC7 3601/4885NOTUM 1736/4885 |
| US-20070043045-A1 | Novel high affinity thiophene-based and furan-based kinase ligands | CDKL2, CDK2, CDKL1 | TRPM5 3235/4885CDC7 47/4885NOTUM 3365/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.