TRPM5 — patent landscape

Top predicted compounds (top 20 by supporting neighbours, then confidence)

Compound	Confidence	Supporting neighbours
SCHEMBL1223564	1.00	20/20
SCHEMBL1223566	1.00	20/20
SCHEMBL1223654	1.00	20/20
SCHEMBL1223655	1.00	20/20
SCHEMBL1223883	1.00	20/20
SCHEMBL1223884	1.00	20/20
SCHEMBL1223953	1.00	20/20
SCHEMBL1223955	1.00	20/20
SCHEMBL1224047	1.00	20/20
SCHEMBL1224048	1.00	20/20
SCHEMBL1224107	1.00	20/20
SCHEMBL1224109	1.00	20/20
SCHEMBL1224205	1.00	20/20
SCHEMBL1224208	1.00	20/20
SCHEMBL1224219	1.00	20/20
SCHEMBL1224220	1.00	20/20
SCHEMBL1224277	1.00	20/20
SCHEMBL1224280	1.00	20/20
SCHEMBL1224556	1.00	20/20
SCHEMBL1224558	1.00	20/20

Clinical trials — most relevant to TRPM5 by text similarity (a relevance ranking, not an exhaustive list)

Trial	Phase	Status
Symptom Response in Normal and Dry Eye Patients Secondary to Application of a Menthol-Containing Eyedrop (Rohto® Hydra)	PHASE4	COMPLETED
Mechanisms of Capsaicin Treatment in Idiopathic Rhinitis Patients and Controls	PHASE4	COMPLETED
TRPV Expression in Subjects With Sensitive Skin	PHASE4	UNKNOWN
The Re-Prosper HF Study	PHASE2/PHASE3	COMPLETED
TRPM8 Activators for Peripheral Neuropathy	PHASE2	ACTIVE_NOT_RECRUITING
Early Study on Tamoxifen Safety/Tolerability in Cystic Fibrosis Patients Unable to Use CFTR Modulators.	PHASE2	NOT_YET_RECRUITING
Calcium Channel Blockade in Primary Aldosteronism	PHASE2	COMPLETED
Assessment of KM-001 - Safety, Tolerability, and Efficacy in Patients With PPPK1 or PC	PHASE1	COMPLETED
Study Designed to Evaluate Safety and Efficacy of 1% Topical Formulation of KM-001 on Type 1 Punctate Palmoplantar Keratoderma or Pachyonychia Congenita Diseases	PHASE1	COMPLETED
Do Acid Sensing Ion Channels Contribute to Heartburn?	PHASE1	COMPLETED
Mechanism of Human Cold Pain Perception - Involvement of TRPA1, TRPM8, Nav1.7 and Nav1.8	EARLY_PHASE1	COMPLETED
Mechanisms of Human Heat Perception - Involvement of TRPA1, TRPV1 and TRPM3	EARLY_PHASE1	COMPLETED
Menthol Stimulation of Brown Adipose Tissue in Humans: Aim 1	EARLY_PHASE1	RECRUITING
Factors Affecting Salt Intake in Young Adults	nan	UNKNOWN
Characterization of New Human Models of Non-histaminergic Itch and Their Interaction With the TRPM8 Receptor	nan	COMPLETED
Identification of TRP Channels as New Potential Therapeutic Targets in Primary and Secondary Raynaud's Phenomenon.	nan	COMPLETED
TRPM2 Gene Polymorphism, NLRP3 Inflammasome Expression in Vitiligo Patients	nan	ACTIVE_NOT_RECRUITING
An Investigation Into the Mechanism of Inhalation Cough Challenge	nan	COMPLETED
The Natural History of TRPV4 Neuropathy	nan	RECRUITING
Dissecting the Heterogeneity of Oral Cancer Pain	nan	UNKNOWN
The Involvement of ATP Sensitive Potassium Channel in Migraine Aura and Migraine Pain.	nan	UNKNOWN
Neurogenic Mechanisms in Burning Mouth Syndrome	nan	COMPLETED
Relationship Between Polymorphisms of TRPV1 and KCC2 Gene in Children With Febrile Seizures	nan	COMPLETED
Effects of Photobiomodulation on the Innate Immune System of Neonates and Infants With Bronchiolitis	nan	UNKNOWN
Effects of an Anti-TRPM8 in the Atopic Dermatitis Pruritus	nan	COMPLETED
Investigation of a New Human Model for Itch	nan	COMPLETED
A Study on the Mechanism of Cough Hypersensitivity	nan	UNKNOWN
Qutenza 8% Capsaicin Topical System for the Treatment of Neuropathic Axial Lower Back Pain and Lumbosacral Radiculopathy	nan	ENROLLING_BY_INVITATION
Manganese-Enhanced Magnetic Resonance Imaging (MEMRI) in Ischaemic, Inflammatory and Takotsubo Cardiomyopathy (MEMORY)	nan	COMPLETED
Classical Trigeminal Neuralgia and Sodium Channel Mutations	nan	COMPLETED

Related proteins — ESM-2 sequence neighbours (a TRPM5 binder may also engage these)

Protein	Name	Similarity
Q9JJH7	—	1.000	Q9JJH7 →
TRPM4	Transient receptor potential cation channel subfamily M member 4	0.979	landscape →
TRPM2	Transient receptor potential cation channel subfamily M member 2	0.977	landscape →
Q91YD4	—	0.972	Q91YD4 →
Q9ESQ5	—	0.965	Q9ESQ5 →
E9PTA2	—	0.964	E9PTA2 →
Q7TN37	—	0.963	Q7TN37 →
Q9R283	—	0.962	Q9R283 →
Q7Z403	—	0.961	Q7Z403 →
SPPL2B	Signal peptide peptidase-like 2B	0.959	landscape →
A1A5B4	—	0.958	A1A5B4 →
MCOLN1	Mucolipin-1	0.958	landscape →
Q60HE8	—	0.957	Q60HE8 →
Q96RR1	—	0.957	Q96RR1 →
Q9UIX4	—	0.957	Q9UIX4 →
A6NDV4	—	0.956	A6NDV4 →
NOX5	NADPH oxidase 5	0.956	landscape →
O95294	—	0.955	O95294 →
Q8NE01	—	0.955	Q8NE01 →
B1AWJ5	—	0.955	B1AWJ5 →
A6QLK4	—	0.954	A6QLK4 →
Q5ZIW1	—	0.953	Q5ZIW1 →
Q9R244	—	0.953	Q9R244 →
Q04671	—	0.953	Q04671 →
Q9DBC0	—	0.952	Q9DBC0 →
Q3TD49	—	0.952	Q3TD49 →
LPCAT1	Lysophosphatidylcholine acyltransferase 1	0.952	landscape →
O43374	—	0.951	O43374 →
S5UH55	—	0.951	S5UH55 →
Q9Z268	—	0.951	Q9Z268 →