SCHEMBL14036170

SCHEMBL14036170

CN(CCN)CCC[C@H](N)C(=O)N[C@H](CCc1ccccc1)C(=O)Nc1ccc2ncccc2c1

nearest known ligand 0.49

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HDAC1 Q13547 7/20 0.49
HDAC4 P56524 2/20 0.48
MEF2D Q14814 1/20 0.48
HDAC3 O15379 1/20 0.44
HDAC7 Q8WUI4 1/20 0.44
HDAC2 Q92769 1/20 0.44
HDAC10 Q969S8 1/20 0.44
HDAC11 Q96DB2 1/20 0.44
HDAC8 Q9BY41 1/20 0.44
HDAC6 Q9UBN7 1/20 0.44
HDAC9 Q9UKV0 1/20 0.44
HDAC5 Q9UQL6 1/20 0.44
PABPC1 P11940 1/20 0.41
NPC1 O15118 2/20 0.39
MEN1 O00255 1/20 0.39
POLB P06746 1/20 0.39
MAPT P10636 1/20 0.39
KMT2A Q03164 1/20 0.39
LTA4H P09960 1/20 0.38
NOTUM Q6P988 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1246012 0.90 HDAC1 (0.54) HDAC1HDAC4MEF2DHDAC3HDAC7
SCHEMBL1244241 0.88 HDAC1 (0.53) HDAC1HDAC4MEF2DHDAC3HDAC7
SCHEMBL10084247 0.86 HDAC1 (0.49) HDAC1HDAC4MEF2DHDAC3HDAC7
SCHEMBL14036176 0.83 HDAC1 (0.44) HDAC1HDAC4HDAC3HDAC7HDAC2
SCHEMBL1245488 0.83 HDAC1 (0.46) HDAC1HDAC4MEF2DMEN1KMT2A
SCHEMBL14036172 0.83 CHRNB2 (0.37) NPC1RAB9ASMN1; SMN2MMP3
SCHEMBL1244183 0.83 HDAC4 (0.48) HDAC1HDAC4MEF2DHDAC3HDAC7
SCHEMBL14036173 0.82 HDAC1 (0.45) HDAC1HDAC4HDAC3HDAC7HDAC2
SCHEMBL5018256 0.82 HDAC1 (0.45) HDAC1HDAC4HDAC3HDAC7HDAC2
SCHEMBL13992005 0.81 HDAC1 (0.44) HDAC1HDAC4HDAC3HDAC7HDAC2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2008141012-A2 QUATERNARY ALKYL AMMONIUM BACTERIAL EFFLUX PUMP INHIBITORS AND THERAPEUTIC USES THEREOF MPEX PHARMACEUTICALS, INC. (US) 2008-11-20 WO disclosed