Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRBN | Q96SW2 | 9/20 | 0.55 |
| ▸ | IKZF2 | Q9UKS7 | 10/20 | 0.54 |
| ▸ | IKZF1 | Q13422 | 2/20 | 0.52 |
| ▸ | CSNK1A1 | P48729 | 2/20 | 0.49 |
| ▸ | GSPT1 | P15170 | 1/20 | 0.46 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.46 |
| ▸ | IKZF3 | Q9UKT9 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4450785 | 0.89 | CRBN (0.52) | CRBNIKZF2IKZF1CSNK1A1DDB1 | |
| SCHEMBL1403510 | 0.88 | CRBN (0.58) | CRBNIKZF2IKZF1CSNK1A1GSPT1 | |
| SCHEMBL22827994 | 0.80 | CRBN (0.69) | CRBNIKZF2IKZF1CSNK1A1 | |
| SCHEMBL1413562 | 0.80 | CRBN (0.56) | CRBNIKZF2IKZF1CSNK1A1GSPT1 | |
| SCHEMBL22609598 | 0.80 | CRBN (0.60) | CRBNIKZF2IKZF1CSNK1A1 | |
| SCHEMBL1413888 | 0.79 | CRBN (0.51) | CRBNIKZF2IKZF1CSNK1A1GSPT1 | |
| SCHEMBL24857646 | 0.78 | IKZF1 (0.58) | IKZF2IKZF1 | |
| SCHEMBL24132372 | 0.78 | IKZF2 (0.68) | CRBNIKZF2IKZF1 | |
| SCHEMBL31205581 | 0.77 | IKZF2 (0.56) | CRBNIKZF2IKZF1CSNK1A1GSPT1 | |
| SCHEMBL29167406 | 0.77 | CRBN (0.54) | CRBNIKZF2IKZF1CSNK1A1GSPT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2291365-A1 | 5-SUBSTITUTED ISOINDOLINE COMPOUNDS | CELGENE CORPORATION (US) | 2011-03-09 | — | — | EP | disclosed |
| WO-2009145899-A1 | 5-SUBSTITUTED ISOINDOLINE COMPOUNDS | CELGENE CORPORATION (US) | 2009-12-03 | — | — | WO | disclosed |