Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IMPDH2 | P12268 | 3/20 | 0.51 |
| ▸ | IMPDH1 | P20839 | 1/20 | 0.50 |
| ▸ | GPR84 | Q9NQS5 | 1/20 | 0.40 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.37 |
| ▸ | CDK9 | P50750 | 1/20 | 0.37 |
| ▸ | HASPIN | Q8TF76 | 1/20 | 0.37 |
| ▸ | SLC6A4 | P31645 | 7/20 | 0.37 |
| ▸ | EP300 | Q09472 | 6/20 | 0.36 |
| ▸ | HAT1 | O14929 | 5/20 | 0.36 |
| ▸ | SLC6A2 | P23975 | 3/20 | 0.36 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | USP2 | O75604 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2300728 | 0.85 | IMPDH2 (0.50) | IMPDH2IMPDH1CCNT1CDK9HASPIN | |
| SCHEMBL13182065 | 0.85 | IMPDH2 (0.48) | IMPDH2IMPDH1GPR84CCNT1CDK9 | |
| SCHEMBL2300147 | 0.84 | SLC6A4 (0.56) | IMPDH2IMPDH1SLC6A4SLC6A2SLC6A3 | |
| SCHEMBL2304617 | 0.81 | IMPDH2 (0.45) | IMPDH2IMPDH1EP300HAT1CYP2D6 | |
| SCHEMBL18412741 | 0.78 | IMPDH2 (0.51) | IMPDH2IMPDH1CCNT1CDK9HASPIN | |
| SCHEMBL2357362 | 0.76 | IMPDH2 (0.48) | IMPDH2IMPDH1CCNT1CDK9HASPIN | |
| SCHEMBL2303415 | 0.75 | IMPDH2 (0.48) | IMPDH2IMPDH1CCNT1CDK9HASPIN | |
| SCHEMBL2300841 | 0.74 | IMPDH2 (0.45) | IMPDH2IMPDH1SLC6A4SLC6A2SLC6A3 | |
| SCHEMBL2300563 | 0.74 | IMPDH2 (0.48) | IMPDH2IMPDH1SLC6A4SLC6A2SLC6A3 | |
| SCHEMBL2302160 | 0.74 | SLC6A4 (0.59) | IMPDH2IMPDH1SLC6A4SLC6A2SLC6A3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7446118-B2 | 3-amino-1-arylpropyl indoles and aza-substituted indoles and uses thereof | ROCHE PALO ALTO LLC (US) | 2008-11-04 | — | — | US | disclosed |