Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 9/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.53 |
| ▸ | POLB | P06746 | 2/20 | 0.53 |
| ▸ | LMNA | P02545 | 1/20 | 0.53 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.46 |
| ▸ | NPC1 | O15118 | 2/20 | 0.43 |
| ▸ | RAB9A | P51151 | 2/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.43 |
| ▸ | HPGD | P15428 | 4/20 | 0.43 |
| ▸ | HTT | P42858 | 2/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.43 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.39 |
| ▸ | RECQL | P46063 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 4/20 | 0.39 |
| ▸ | CYP19A1 | P11511 | 4/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14257271 | 0.86 | KDM4E (0.47) | KDM4EALDH1A1POLBLMNARXFP1 | |
| SCHEMBL14039386 | 0.83 | KDM4E (0.44) | KDM4EALDH1A1POLBLMNARXFP1 | |
| SCHEMBL4708598 | 0.82 | KDM4E (0.51) | KDM4EALDH1A1POLBLMNARXFP1 | |
| SCHEMBL14038870 | 0.81 | KDM4E (0.43) | KDM4EALDH1A1POLBLMNARXFP1 | |
| SCHEMBL14039389 | 0.80 | HRH3 (0.43) | KDM4EALDH1A1POLBLMNARXFP1 | |
| SCHEMBL14038851 | 0.79 | KDM4E (0.41) | KDM4EALDH1A1POLBLMNARXFP1 | |
| SCHEMBL14014373 | 0.73 | SMN1; SMN2 (0.65) | KDM4EALDH1A1POLBLMNARXFP1 | |
| SCHEMBL14039334 | 0.73 | KDM4E (0.41) | KDM4EALDH1A1LMNASMN1; SMN2HPGD | |
| SCHEMBL14014391 | 0.71 | GRM2 (0.48) | KDM4EALDH1A1POLBLMNARXFP1 | |
| SCHEMBL4709978 | 0.71 | GRM2 (0.48) | KDM4EALDH1A1POLBLMNARXFP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7449488-B2 | Pyrazolopyrimidines as protein kinase inhibitors | SCHERING CORPORATION (US) | 2008-11-11 | — | — | US | disclosed |
| WO-2007044410-A1 | PYRAZOLO [1,5-A] PYRIMIDINES AS PROTEIN KINASE INHIBITORS | SCHERING CORPORATION (US) | 2007-04-19 | — | — | WO | disclosed |
| US-7196111-B2 | Pyrazolo[1,5a]pyrimidine compounds as antiviral agents | SCHERING CORPORATION (US) | 2007-03-27 | — | — | US | disclosed |