Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.65 |
| ▸ | CSNK2A1 | P68400 | 3/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.53 |
| ▸ | LMNA | P02545 | 2/20 | 0.53 |
| ▸ | POLB | P06746 | 1/20 | 0.53 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.48 |
| ▸ | NPC1 | O15118 | 1/20 | 0.48 |
| ▸ | RAB9A | P51151 | 1/20 | 0.48 |
| ▸ | KDR | P35968 | 5/20 | 0.45 |
| ▸ | KDM4D | Q6B0I6 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.42 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.42 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.42 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.42 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14014460 | 0.85 | ALDH1A1 (0.50) | SMN1; SMN2CSNK2A1KDM4EALDH1A1LMNA | |
| SCHEMBL4707789 | 0.85 | SMN1; SMN2 (0.49) | SMN1; SMN2CSNK2A1KDM4EALDH1A1LMNA | |
| SCHEMBL14014371 | 0.83 | KDM4E (0.59) | SMN1; SMN2CSNK2A1KDM4EALDH1A1LMNA | |
| SCHEMBL4709978 | 0.81 | GRM2 (0.48) | SMN1; SMN2KDM4EALDH1A1LMNAPOLB | |
| SCHEMBL14014391 | 0.81 | GRM2 (0.48) | SMN1; SMN2KDM4EALDH1A1LMNAPOLB | |
| SCHEMBL14014472 | 0.81 | SMN1; SMN2 (0.56) | SMN1; SMN2CSNK2A1KDM4EALDH1A1LMNA | |
| SCHEMBL4706821 | 0.80 | KDM4E (0.52) | SMN1; SMN2CSNK2A1KDM4EALDH1A1LMNA | |
| SCHEMBL4708050 | 0.80 | KDM4E (0.52) | SMN1; SMN2CSNK2A1KDM4EALDH1A1LMNA | |
| SCHEMBL29071807 | 0.79 | SMN1; SMN2 (1.00) | SMN1; SMN2CSNK2A1KDM4EALDH1A1LMNA | |
| SCHEMBL14014378 | 0.76 | KDM4E (0.65) | SMN1; SMN2KDM4EALDH1A1LMNAKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7449488-B2 | Pyrazolopyrimidines as protein kinase inhibitors | SCHERING CORPORATION (US) | 2008-11-11 | — | — | US | disclosed |
| US-7449488-B2 | Pyrazolopyrimidines as protein kinase inhibitors | SCHERING CORPORATION (US) | 2008-11-11 | — | — | US | disclosed |
| US-7196111-B2 | Pyrazolo[1,5a]pyrimidine compounds as antiviral agents | SCHERING CORPORATION (US) | 2007-03-27 | — | — | US | disclosed |
| US-7196111-B2 | Pyrazolo[1,5a]pyrimidine compounds as antiviral agents | SCHERING CORPORATION (US) | 2007-03-27 | — | — | US | disclosed |