Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 14/20 | 0.49 |
| ▸ | RAB9A | P51151 | 13/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 9/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.49 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.47 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.47 |
| ▸ | RELA | Q04206 | 1/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | TP53 | P04637 | 2/20 | 0.44 |
| ▸ | GCK | P35557 | 1/20 | 0.43 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.43 |
| ▸ | TOP1 | P11387 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14039457 | 0.86 | NPC1 (0.52) | NPC1RAB9ASMN1; SMN2ALDH1A1KDM4E | |
| SCHEMBL3602578 | 0.81 | GCK (0.58) | NPC1RAB9ASMN1; SMN2GCKKCNH2 | |
| SCHEMBL13255168 | 0.81 | GCK (0.58) | NPC1RAB9ASMN1; SMN2GCKKCNH2 | |
| SCHEMBL13072160 | 0.72 | GCK (0.61) | NPC1RAB9ASMN1; SMN2ALDH1A1KDM4E | |
| SCHEMBL13888123 | 0.70 | NPC1 (0.69) | NPC1RAB9ASMN1; SMN2ALDH1A1KDM4E | |
| SCHEMBL12510624 | 0.69 | NPC1 (0.56) | NPC1RAB9ASMN1; SMN2ALDH1A1KDM4E | |
| SCHEMBL12510371 | 0.69 | NPC1 (0.52) | NPC1RAB9ASMN1; SMN2ALDH1A1KDM4E | |
| SCHEMBL2665320 | 0.68 | NPC1 (0.66) | NPC1RAB9ASMN1; SMN2ALDH1A1KDM4E | |
| SCHEMBL13071804 | 0.68 | NPC1 (0.73) | NPC1RAB9ASMN1; SMN2ALDH1A1KDM4E | |
| SCHEMBL3604793 | 0.68 | GCK (0.64) | NPC1RAB9ASMN1; SMN2GCKKCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7432287-B2 | Heteroarylcarbamoylbenzene derivative | BANYU PHARMECEUTICAL CO., LTD. (JP) | 2008-10-07 | — | — | US | disclosed |