Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLA2G2A | P14555 | 4/20 | 0.77 |
| ▸ | PLA2G10 | O15496 | 1/20 | 0.67 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.66 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.64 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.63 |
| ▸ | MEN1 | O00255 | 2/20 | 0.63 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.63 |
| ▸ | CA12 | O43570 | 2/20 | 0.62 |
| ▸ | CA1 | P00915 | 2/20 | 0.62 |
| ▸ | CA2 | P00918 | 2/20 | 0.62 |
| ▸ | CA9 | Q16790 | 2/20 | 0.62 |
| ▸ | TACR3 | P29371 | 2/20 | 0.59 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.58 |
| ▸ | MAPT | P10636 | 3/20 | 0.58 |
| ▸ | HPGD | P15428 | 2/20 | 0.57 |
| ▸ | NPC1 | O15118 | 2/20 | 0.57 |
| ▸ | RAB9A | P51151 | 2/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.57 |
| ▸ | LMNA | P02545 | 1/20 | 0.57 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29864792 | 0.91 | TACR3 (0.71) | PLA2G2APLA2G10RXFP1KDM4ESMN1; SMN2 | |
| SCHEMBL245078 | 0.89 | PLA2G2A (0.81) | PLA2G2AKDM4ESMN1; SMN2MEN1KMT2A | |
| SCHEMBL13957891 | 0.87 | PLA2G2A (0.77) | PLA2G2AKDM4ESMN1; SMN2MEN1KMT2A | |
| SCHEMBL13963326 | 0.85 | PLA2G2A (0.58) | PLA2G2APLA2G10KDM4ESMN1; SMN2MEN1 | |
| SCHEMBL4601889 | 0.85 | MEN1 (0.66) | PLA2G2AKDM4ESMN1; SMN2MEN1KMT2A | |
| SCHEMBL8620936 | 0.85 | PLA2G2A (0.69) | PLA2G2AKDM4ESMN1; SMN2MEN1KMT2A | |
| SCHEMBL27865637 | 0.82 | KDM4E (0.79) | RXFP1KDM4ESMN1; SMN2MEN1KMT2A | |
| Benzaldehyde SCHEMBL22471923 | 0.82 | PLA2G2A (0.69) | PLA2G2AKDM4ESMN1; SMN2MEN1KMT2A | |
| SCHEMBL4600353 | 0.82 | KDM4E (0.71) | PLA2G2AKDM4ESMN1; SMN2MEN1KMT2A | |
| SCHEMBL4189945 | 0.80 | TACR3 (0.74) | PLA2G2AKDM4ESMN1; SMN2MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008116671-A1 | 2,3,4,9-TETRAHYDRO-1H-CARBAZOLES | BAYER SCHERING PHARMA AKTIENGESELLSCHAFT (DE) | 2008-10-02 | — | — | WO | disclosed |
| EP-1975159-A1 | 2,3,4,9-Tetrahydro-1H-carbazoles | Bayer Schering Pharma Aktiengesellschaft (DE) | 2008-10-01 | — | — | EP | disclosed |