Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP2K1 | Q02750 | 16/20 | 0.79 |
| ▸ | RAF1 | P04049 | 2/20 | 0.68 |
| ▸ | MAPK3 | P27361 | 1/20 | 0.68 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.68 |
| ▸ | SRC | P12931 | 2/20 | 0.61 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.56 |
| ▸ | IGF1R | P08069 | 1/20 | 0.56 |
| ▸ | EGFR | P00533 | 1/20 | 0.55 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.55 |
| ▸ | ABL1 | P00519 | 1/20 | 0.55 |
| ▸ | BCR | P11274 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14040749 | 0.93 | MAP2K1 (0.79) | MAP2K1RAF1MAPK3MAPK1SRC | |
| SCHEMBL6993386 | 0.88 | MAP2K1 (1.00) | MAP2K1RAF1MAPK3MAPK1SRC | |
| SCHEMBL4447904 | 0.86 | MAP2K1 (0.72) | MAP2K1RAF1MAPK3MAPK1SRC | |
| SCHEMBL14155226 | 0.86 | MAP2K1 (0.67) | MAP2K1RAF1MAPK3MAPK1SRC | |
| SCHEMBL12856346 | 0.81 | MAP2K1 (0.80) | MAP2K1RAF1MAPK3MAPK1SRC | |
| SCHEMBL6991654 | 0.81 | MAP2K1 (0.87) | MAP2K1RAF1MAPK3MAPK1SRC | |
| SCHEMBL346145 | 0.81 | MAP2K1 (1.00) | MAP2K1RAF1MAPK3MAPK1SRC | |
| SCHEMBL4448781 | 0.80 | MAP2K1 (0.84) | MAP2K1RAF1MAPK3MAPK1SRC | |
| SCHEMBL4447835 | 0.79 | MAP2K1 (0.64) | MAP2K1RAF1MAPK3MAPK1SRC | |
| SCHEMBL14040731 | 0.79 | SRC (0.78) | MAP2K1SRCEGFRERBB2ABL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1975620-A2 | Three hybrid assay system | GPC Biotech AG (DE) | 2008-10-01 | — | — | EP | disclosed |