Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP2K1 | Q02750 | 18/20 | 1.00 |
| ▸ | RAF1 | P04049 | 2/20 | 0.87 |
| ▸ | MAPK3 | P27361 | 1/20 | 0.87 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.87 |
| ▸ | IGF1R | P08069 | 1/20 | 0.72 |
| ▸ | EGFR | P00533 | 1/20 | 0.71 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.71 |
| ▸ | ABL1 | P00519 | 1/20 | 0.71 |
| ▸ | BCR | P11274 | 1/20 | 0.71 |
| ▸ | SRC | P12931 | 1/20 | 0.71 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL346145 | 0.93 | MAP2K1 (1.00) | MAP2K1RAF1MAPK3MAPK1IGF1R | |
| SCHEMBL6991654 | 0.93 | MAP2K1 (0.87) | MAP2K1RAF1MAPK3MAPK1IGF1R | |
| SCHEMBL4448781 | 0.91 | MAP2K1 (0.84) | MAP2K1RAF1MAPK3MAPK1IGF1R | |
| SCHEMBL4451324 | 0.91 | MAP2K1 (0.90) | MAP2K1RAF1MAPK3MAPK1IGF1R | |
| SCHEMBL4454646 | 0.91 | MAP2K1 (1.00) | MAP2K1RAF1MAPK3MAPK1IGF1R | |
| SCHEMBL4447752 | 0.90 | MAP2K1 (0.86) | MAP2K1RAF1MAPK3MAPK1IGF1R | |
| SCHEMBL6995929 | 0.90 | MAP2K1 (0.85) | MAP2K1RAF1MAPK3MAPK1IGF1R | |
| SCHEMBL14040784 | 0.88 | MAP2K1 (0.79) | MAP2K1RAF1MAPK3MAPK1IGF1R | |
| SCHEMBL14116957 | 0.86 | MAP2K1 (0.82) | MAP2K1RAF1MAPK3MAPK1IGF1R | |
| SCHEMBL4447762 | 0.85 | MAP2K1 (0.81) | MAP2K1RAF1MAPK3MAPK1IGF1R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1117659-B1 | SUBSTITUTED 3-CYANOQUINOLINES AS PROTEIN TYROSINE KINASES INHIBITORS | WYETH CORP (US) | 2003-12-03 | — | — | EP | claimed |
| US-6288082-B1 | COMPOUNDS SUCH AS 6,7-DIETHOXY-4-(INDAN-5-YLAMINO) -QUINOLINE-3-CARBONITRILE USED AS ANTINEOPLASTIC AGENTS AND IN THE TREATMENT OF POLYCYCSTIC KIDNEY DISEASE | AMERICAN CYANAMID COMPANY | 2001-09-11 | — | — | US | claimed |
| EP-1117659-A1 | SUBSTITUTED 3-CYANOQUINOLINES AS PROTEIN TYROSINE KINASES INHIBITORS | American Cyanamid Company (US) | 2001-07-25 | — | — | EP | claimed |
| WO-2000018761-A1 | SUBSTITUTED 3-CYANOQUINOLINES AS PROTEIN TYROSINE KINASES INHIBITORS | AMERICAN CYANAMID COMPANY (US) | 2000-04-06 | — | — | WO | claimed |