Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGDS | O60760 | 6/20 | 0.51 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.39 |
| ▸ | MAOB | P27338 | 1/20 | 0.37 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | IDO1 | P14902 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | WNT3A | P56704 | 1/20 | 0.35 |
| ▸ | POLQ | O75417 | 1/20 | 0.34 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3217764 | 0.92 | HPGDS (0.54) | HPGDSDGAT1CSNK1DMEN1KMT2A | |
| SCHEMBL12083978 | 0.90 | HPGDS (0.49) | HPGDSDGAT1MAOBMEN1KMT2A | |
| SCHEMBL12083923 | 0.88 | HPGDS (0.54) | HPGDSDGAT1CSNK1D | |
| SCHEMBL3810374 | 0.88 | HPGDS (0.51) | HPGDSDGAT1CSNK1DIDO1POLQ | |
| SCHEMBL12083909 | 0.88 | HPGDS (0.51) | HPGDSDGAT1CSNK1DPOLQMAP4K4 | |
| SCHEMBL2471757 | 0.88 | HPGDS (0.54) | HPGDSDGAT1CSNK1DMEN1KMT2A | |
| SCHEMBL12083724 | 0.86 | HPGDS (0.50) | HPGDSCSNK1DLMNAMAPTPOLQ | |
| SCHEMBL12084048 | 0.86 | HPGDS (0.49) | HPGDSDGAT1CSNK1DMAP4K4 | |
| SCHEMBL12084161 | 0.85 | HPGDS (0.49) | HPGDSCSNK1DMEN1KMT2ALMNA | |
| SCHEMBL3717427 | 0.84 | HPGDS (0.51) | HPGDSDGAT1CSNK1DPOLQMAP4K4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008121670-A1 | PYRIMIDINE HYDRAZIDE COMPOUNDS AS PGDS INHIBITORS | SANOFI-AVENTIS (FR) | 2008-10-09 | — | — | WO | disclosed |