Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK2 | P24941 | 13/20 | 0.58 |
| ▸ | GSK3B | P49841 | 7/20 | 0.57 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.48 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.48 |
| ▸ | CCNE1 | P24864 | 7/20 | 0.47 |
| ▸ | ERCC1 | P07992 | 1/20 | 0.43 |
| ▸ | ERCC4 | Q92889 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13119425 | 0.92 | CDK2 (0.69) | CDK2GSK3BCCNA2CCNA1CCNE1 | |
| SCHEMBL13119519 | 0.91 | CDK2 (0.68) | CDK2GSK3BCCNA2CCNA1CCNE1 | |
| SCHEMBL13119446 | 0.91 | CDK2 (0.68) | CDK2GSK3BCCNA2CCNA1CCNE1 | |
| SCHEMBL14581649 | 0.89 | CDK2 (0.54) | CDK2GSK3BCCNA2CCNA1CCNE1 | |
| SCHEMBL14043437 | 0.89 | CDK2 (0.44) | CDK2GSK3BCCNE1ERCC1ERCC4 | |
| SCHEMBL13119420 | 0.89 | CDK2 (0.72) | CDK2GSK3BCCNA2CCNA1CCNE1 | |
| SCHEMBL13119277 | 0.87 | CDK2 (0.65) | CDK2GSK3BCCNA2CCNA1CCNE1 | |
| SCHEMBL13119418 | 0.86 | CDK2 (0.64) | CDK2GSK3BCCNA2CCNA1CCNE1 | |
| SCHEMBL13119325 | 0.86 | CDK2 (0.64) | CDK2GSK3BCCNA2CCNA1CCNE1 | |
| SCHEMBL14301724 | 0.86 | GSK3B (0.57) | CDK2GSK3BCCNA2CCNA1CCNE1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008130570-A1 | NOVEL PYRAZOLOPYRIMIDINES AS CYCLIN DEPENDENT KINASE INHIBITORS | SCHERING CORPORATION (US) | 2008-10-30 | — | — | WO | disclosed |