Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK2 | P24941 | 6/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | GSK3B | P49841 | 2/20 | 0.43 |
| ▸ | ERCC1 | P07992 | 1/20 | 0.43 |
| ▸ | ERCC4 | Q92889 | 1/20 | 0.43 |
| ▸ | AKT1 | P31749 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | WDR5 | P61964 | 1/20 | 0.42 |
| ▸ | USP2 | O75604 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | SMO | Q99835 | 1/20 | 0.41 |
| ▸ | CDK9 | P50750 | 2/20 | 0.40 |
| ▸ | CDK1 | P06493 | 1/20 | 0.40 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14043167 | 0.89 | CDK2 (0.58) | CDK2GSK3BERCC1ERCC4CCNE1 | |
| SCHEMBL14301732 | 0.87 | PDK1 (0.41) | CDK2MEN1KMT2AGSK3BCDK9 | |
| SCHEMBL14613294 | 0.85 | CDK2 (0.46) | CDK2GSK3BERCC1ERCC4HPGD | |
| SCHEMBL12954351 | 0.84 | BDKRB2 (0.42) | CDK2MEN1KMT2AGSK3BCDK9 | |
| SCHEMBL13288645 | 0.82 | CDK2 (0.54) | CDK2MEN1KMT2AGSK3BAKT1 | |
| SCHEMBL13119446 | 0.82 | CDK2 (0.68) | CDK2GSK3BCCNE1 | |
| SCHEMBL13119519 | 0.82 | CDK2 (0.68) | CDK2GSK3BCCNE1 | |
| SCHEMBL14043231 | 0.81 | GSK3B (0.50) | CDK2MEN1KMT2AGSK3BNPC1 | |
| SCHEMBL13119425 | 0.81 | CDK2 (0.69) | CDK2GSK3BCCNE1 | |
| SCHEMBL14301725 | 0.79 | SMO (0.45) | CDK2MEN1KMT2AGSK3BUSP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008130570-A1 | NOVEL PYRAZOLOPYRIMIDINES AS CYCLIN DEPENDENT KINASE INHIBITORS | SCHERING CORPORATION (US) | 2008-10-30 | — | — | WO | disclosed |