Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 3/20 | 0.46 |
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
| ▸ | NPC1 | O15118 | 2/20 | 0.46 |
| ▸ | RAB9A | P51151 | 2/20 | 0.46 |
| ▸ | GSK3B | P49841 | 8/20 | 0.43 |
| ▸ | CDK2 | P24941 | 10/20 | 0.41 |
| ▸ | CCNE1 | P24864 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14050875 | 0.85 | GSK3B (0.43) | KMT2AMEN1NPC1RAB9AGSK3B | |
| SCHEMBL14043196 | 0.84 | GSK3B (0.42) | KMT2AMEN1NPC1RAB9AGSK3B | |
| SCHEMBL13305626 | 0.82 | CDK2 (0.62) | GSK3BCDK2CCNE1 | |
| SCHEMBL12954361 | 0.81 | GSK3B (0.42) | KMT2AMEN1NPC1RAB9AGSK3B | |
| SCHEMBL12953809 | 0.80 | RAB9A (0.43) | KMT2AMEN1NPC1RAB9AGSK3B | |
| SCHEMBL14301781 | 0.80 | RET (0.46) | KMT2AMEN1NPC1RAB9AGSK3B | |
| SCHEMBL14301243 | 0.80 | GSK3B (0.48) | KMT2AMEN1NPC1RAB9AGSK3B | |
| SCHEMBL13305690 | 0.79 | CDK2 (0.53) | KMT2AMEN1NPC1RAB9AGSK3B | |
| SCHEMBL14418832 | 0.78 | KCNK3 (0.41) | KMT2AMEN1NPC1RAB9AGSK3B | |
| SCHEMBL12953974 | 0.77 | SIRT2 (0.40) | KMT2AMEN1GSK3BCDK2CCNE1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008130570-A1 | NOVEL PYRAZOLOPYRIMIDINES AS CYCLIN DEPENDENT KINASE INHIBITORS | SCHERING CORPORATION (US) | 2008-10-30 | — | — | WO | disclosed |