SCHEMBL1404474

SCHEMBL1404474

CC(C)(C)OC(=O)NCCN(CC(=O)O)C(=O)Cn1cnc2c(OCc3ccccc3)ncnc21

nearest known ligand 0.47

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
DAPK1 P53355 3/20 0.47
GALR3 O60755 1/20 0.44
NR2F2 P24468 1/20 0.44
FLT4 P35916 1/20 0.42
KDR P35968 1/20 0.42
CKS1B P61024 1/20 0.40
SKP1 P63208 1/20 0.40
SKP2 Q13309 1/20 0.40
SLC29A1 Q99808 2/20 0.36
HPGD P15428 1/20 0.35
TDP1 Q9NUW8 1/20 0.35
CCNE2 O96020 1/20 0.35
CCNE1 P24864 1/20 0.35
CDK2 P24941 1/20 0.35
HDAC1 Q13547 1/20 0.35
HDAC2 Q92769 1/20 0.35
IDO1 P14902 1/20 0.35
SIGMAR1 Q99720 2/20 0.35
GHSR Q92847 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL17739752 0.92 GALR3 (0.40) DAPK1GALR3NR2F2FLT4KDR
SCHEMBL2684979 0.88 MGMT (0.40) DAPK1GALR3NR2F2CKS1BSKP1
SCHEMBL6803680 0.88 TDP1 (0.40) CKS1BSKP1SKP2TDP1CCNE2
SCHEMBL23453050 0.86 TDP1 (0.40) GALR3NR2F2CKS1BSKP1SKP2
SCHEMBL12436866 0.84 DAPK1 (0.55) DAPK1GALR3NR2F2FLT4KDR
SCHEMBL18087389 0.84 FLT4 (0.35) GALR3NR2F2FLT4KDRCKS1B
SCHEMBL23453058 0.83 HDAC1 (0.41) CKS1BSKP1SKP2TDP1CCNE2
SCHEMBL8649567 0.83 CKS1B (0.40) FLT4KDRCKS1BSKP1SKP2
SCHEMBL1404477 0.82 DAPK1 (0.47) DAPK1GALR3NR2F2FLT4KDR
SCHEMBL430139 0.81 CKS1B (0.36) CKS1BSKP1SKP2CCNE2CCNE1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 50 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-10036066-B2 In situ hybridization detection method DAKO DENMARK A/S (DK) 2018-07-31 US disclosed
US-10036066-B2 In situ hybridization detection method DAKO DENMARK A/S (DK) 2018-07-31 US disclosed
US-9598720-B2 Monomeric and polymeric linkers useful for conjugating biological molecules and other substances DAKO DENMARK A/S (DK) 2017-03-21 US disclosed
US-9598720-B2 Monomeric and polymeric linkers useful for conjugating biological molecules and other substances DAKO DENMARK A/S (DK) 2017-03-21 US disclosed
US-20160273035-A1 IN SITU HYBRIDIZATION DETECTION METHOD DAKO DENMARK A/S (DK) 2016-09-22 US disclosed
EP-1919930-B1 NEW NUCLEIC ACID BASE PAIRS DAKO DENMARK AS (DK) 2016-09-14 EP disclosed
US-9340824-B2 Immunohistochemistry detection method DAKO DENMARK A/S (DK) 2016-05-17 US disclosed
US-9017992-B2 In situ hybridization detection method DAKO DENMARK A/S (DK) 2015-04-28 US disclosed
US-9017992-B2 In situ hybridization detection method DAKO DENMARK A/S (DK) 2015-04-28 US disclosed
US-9017992-B2 In situ hybridization detection method DAKO DENMARK A/S (DK) 2015-04-28 US disclosed
US-20100105030-A1 NUCLEIC ACID BASE PAIRS DAKO DENMARK A/S (DK) 2010-04-29 US disclosed
EP-1919930-A2 NEW NUCLEIC ACID BASE PAIRS Dako Denmark A/S (DK) 2008-05-14 EP disclosed
EP-1920073-A2 METHOD OF SIMULTANEOUSLY VISUALIZING MULTIPLE BIOLOGICAL TARGETS Dako Denmark A/S (DK) 2008-05-14 EP disclosed
EP-1920072-A2 IN SITU HYBRIDIZATION DETECTION METHOD Dako Denmark A/S (DK) 2008-05-14 EP disclosed
EP-1907592-A2 MONOMERIC AND POLYMERIC LINKERS USEFUL FOR CONJUGATING BIOLOGICAL MOLECULES AND OTHER SUBSTANCES Dako Denmark A/S (DK) 2008-04-09 EP disclosed
WO-2007031874-A9 METHOD OF SIMULTANEOUSLY VISUALIZING MULTIPLE BIOLOGICAL TARGETS DAKO DENMARK AS (DK) 2007-05-31 WO disclosed
WO-2007045998-A2 NEW NUCLEIC ACID BASE PAIRS DAKO DENMARK A/S (US) 2007-04-26 WO disclosed
WO-2007031874-A2 METHOD OF SIMULTANEOUSLY VISUALIZING MULTIPLE BIOLOGICAL TARGETS DAKO DENMARK A/S (US) 2007-03-22 WO disclosed
WO-2007026252-A2 IN SITU HYBRIDIZATION DETECTION METHOD DAKO DENMARK A/S (US) 2007-03-08 WO disclosed
WO-2007015168-A2 MONOMERIC AND POLYMERIC LINKERS USEFUL FOR CONJUGATING BIOLOGICAL MOLECULES AND OTHER SUBSTANCES DAKO DENMARK A/S (US) 2007-02-08 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20100105030-A1 NUCLEIC ACID BASE PAIRS NSUN3, NCL, NSUN2 DAPK1 3183/4885GALR3 3330/4885NR2F2 3010/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.