SCHEMBL1404477

SCHEMBL1404477

CC(C)(C)OC(=O)C(N)CN(CC(=O)O)C(=O)Cn1cnc2c(OCc3ccccc3)ncnc21

nearest known ligand 0.47

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
DAPK1 P53355 3/20 0.47
GALR3 O60755 1/20 0.44
NR2F2 P24468 1/20 0.44
FLT4 P35916 1/20 0.42
KDR P35968 1/20 0.42
LTA4H P09960 1/20 0.38
SLC29A1 Q99808 1/20 0.36
EGFR P00533 1/20 0.36
HPGD P15428 2/20 0.35
PDE4A P27815 1/20 0.34
PDE4B Q07343 1/20 0.34
PDE4C Q08493 1/20 0.34
PDE4D Q08499 1/20 0.34
NPC1 O15118 1/20 0.33
TP53 P04637 1/20 0.33
RAB9A P51151 1/20 0.33
ALDH1A1 P00352 1/20 0.33
LMNA P02545 1/20 0.33
TSHR P16473 1/20 0.33
MAPK1 P28482 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2684987 0.89 MGMT (0.40) DAPK1GALR3NR2F2FLT4KDR
SCHEMBL1404474 0.82 DAPK1 (0.47) DAPK1GALR3NR2F2FLT4KDR
SCHEMBL12436866 0.81 DAPK1 (0.55) DAPK1GALR3NR2F2FLT4KDR
SCHEMBL432837 0.80 CCNE2 (0.37) LTA4HNPC1TP53RAB9A
SCHEMBL17739752 0.77 GALR3 (0.40) DAPK1GALR3NR2F2FLT4KDR
SCHEMBL1404491 0.75 DAPK1 (0.72) DAPK1GALR3NR2F2FLT4KDR
SCHEMBL6240613 0.73 JAK2 (0.41) SLC29A1PDE4APDE4BPDE4CPDE4D
SCHEMBL2684979 0.72 MGMT (0.40) DAPK1GALR3NR2F2
SCHEMBL6803680 0.72 TDP1 (0.40) PDE4APDE4BPDE4CPDE4DHTT
SCHEMBL8005733 0.72 LTA4H (0.31) LTA4H

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 27 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-10036066-B2 In situ hybridization detection method DAKO DENMARK A/S (DK) 2018-07-31 US disclosed
US-9598720-B2 Monomeric and polymeric linkers useful for conjugating biological molecules and other substances DAKO DENMARK A/S (DK) 2017-03-21 US disclosed
US-20160273035-A1 IN SITU HYBRIDIZATION DETECTION METHOD DAKO DENMARK A/S (DK) 2016-09-22 US disclosed
EP-1919930-B1 NEW NUCLEIC ACID BASE PAIRS DAKO DENMARK AS (DK) 2016-09-14 EP disclosed
US-9017992-B2 In situ hybridization detection method DAKO DENMARK A/S (DK) 2015-04-28 US disclosed
EP-1910575-B1 IMMUNOHISTOCHEMISTRY DETECTION METHOD DAKO DENMARK AS (DK) 2014-12-10 EP disclosed
US-20140315204-A1 Immunohistochemistry Detection Method DAKO DENMARK A/S (DK) 2014-10-23 US disclosed
US-8741566-B2 Immunohistochemistry and in situ hybridization detection method DAKO DENMARK A/S (DK) 2014-06-03 US disclosed
US-20140080145-A1 Monomeric and Polymeric Linkers Useful For Conjugating Biological Molecules and Other Substances DAKO DENMARK A/S (DK) 2014-03-20 US disclosed
US-8546309-B2 Monomeric and polymeric linkers useful for conjugating biological molecules and other substances DAKO DENMARK A/S (DK) 2013-10-01 US disclosed
US-20100105030-A1 NUCLEIC ACID BASE PAIRS DAKO DENMARK A/S (DK) 2010-04-29 US disclosed
EP-1919930-A2 NEW NUCLEIC ACID BASE PAIRS Dako Denmark A/S (DK) 2008-05-14 EP disclosed
EP-1920073-A2 METHOD OF SIMULTANEOUSLY VISUALIZING MULTIPLE BIOLOGICAL TARGETS Dako Denmark A/S (DK) 2008-05-14 EP disclosed
EP-1920072-A2 IN SITU HYBRIDIZATION DETECTION METHOD Dako Denmark A/S (DK) 2008-05-14 EP disclosed
EP-1907592-A2 MONOMERIC AND POLYMERIC LINKERS USEFUL FOR CONJUGATING BIOLOGICAL MOLECULES AND OTHER SUBSTANCES Dako Denmark A/S (DK) 2008-04-09 EP disclosed
WO-2007031874-A9 METHOD OF SIMULTANEOUSLY VISUALIZING MULTIPLE BIOLOGICAL TARGETS DAKO DENMARK AS (DK) 2007-05-31 WO disclosed
WO-2007045998-A2 NEW NUCLEIC ACID BASE PAIRS DAKO DENMARK A/S (US) 2007-04-26 WO disclosed
WO-2007031874-A2 METHOD OF SIMULTANEOUSLY VISUALIZING MULTIPLE BIOLOGICAL TARGETS DAKO DENMARK A/S (US) 2007-03-22 WO disclosed
WO-2007026252-A2 IN SITU HYBRIDIZATION DETECTION METHOD DAKO DENMARK A/S (US) 2007-03-08 WO disclosed
WO-2007015168-A2 MONOMERIC AND POLYMERIC LINKERS USEFUL FOR CONJUGATING BIOLOGICAL MOLECULES AND OTHER SUBSTANCES DAKO DENMARK A/S (US) 2007-02-08 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20140080145-A1 Monomeric and Polymeric Linkers Useful For Conjugating Biological Molecules and Other Substances PCNA, DCLRE1A, TK1 DAPK1 2106/4885GALR3 2296/4885NR2F2 4580/4885
US-20100105030-A1 NUCLEIC ACID BASE PAIRS NSUN3, NCL, NSUN2 DAPK1 3183/4885GALR3 3330/4885NR2F2 3010/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.