Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 12/20 | 0.51 |
| ▸ | RAB9A | P51151 | 12/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.51 |
| ▸ | HKDC1 | Q2TB90 | 1/20 | 0.51 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.51 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.45 |
| ▸ | DYRK1A | Q13627 | 4/20 | 0.45 |
| ▸ | GFER | P55789 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 7/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 7/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | DYRK2 | Q92630 | 3/20 | 0.39 |
| ▸ | DYRK1B | Q9Y463 | 3/20 | 0.39 |
| ▸ | CSNK2A2 | P19784 | 2/20 | 0.39 |
| ▸ | CLK1 | P49759 | 2/20 | 0.39 |
| ▸ | CSNK2B | P67870 | 2/20 | 0.39 |
| ▸ | CSNK2A1 | P68400 | 2/20 | 0.39 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26631999 | 0.81 | NPC1 (0.34) | NPC1RAB9AKDM4EHKDC1TDP1 | |
| SCHEMBL3396673 | 0.74 | NPC1 (0.53) | NPC1RAB9AKDM4EHKDC1TDP1 | |
| SCHEMBL2091083 | 0.74 | NPC1 (0.56) | NPC1RAB9AKDM4EHKDC1TDP1 | |
| SCHEMBL27712149 | 0.73 | NPC1 (0.47) | NPC1RAB9AKDM4EHKDC1TDP1 | |
| SCHEMBL11976454 | 0.71 | NPC1 (0.53) | NPC1RAB9AKDM4EHKDC1TDP1 | |
| SCHEMBL742714 | 0.70 | ALDH1A1 (0.50) | NPC1RAB9AKDM4EHKDC1TDP1 | |
| SCHEMBL593507 | 0.69 | NPC1 (0.54) | NPC1RAB9AKDM4EHKDC1TDP1 | |
| SCHEMBL927553 | 0.69 | NPC1 (0.52) | NPC1RAB9AKDM4EHKDC1TDP1 | |
| SCHEMBL2010188 | 0.69 | NPC1 (0.52) | NPC1RAB9AKDM4EHKDC1TDP1 | |
| SCHEMBL14204750 | 0.69 | NPC1 (0.52) | NPC1RAB9AKDM4EHKDC1TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105712949-A | 6-benzothiazole sulfonyl derivative and preparation method thereof | 叶芳 | 2016-06-29 | — | — | CN | claimed |
| CN-116354903-A | Preparation method of 6-benzothiazole sulfonyl chloride | 南京药石科技股份有限公司 | 2023-06-30 | — | — | CN | disclosed |
| CN-105712949-A | 6-benzothiazole sulfonyl derivative and preparation method thereof | 叶芳 | 2016-06-29 | — | — | CN | disclosed |
| CN-105712949-A | 6-benzothiazole sulfonyl derivative and preparation method thereof | 叶芳 | 2016-06-29 | — | — | CN | disclosed |
| CN-105712949-A | 6-benzothiazole sulfonyl derivative and preparation method thereof | 叶芳 | 2016-06-29 | — | — | CN | disclosed |
| WO-2012055034-A1 | SULFONAMIDES AS HIV PROTEASE INHIBITORS | MERCK CANADA INC. (CA) | 2012-05-03 | — | — | WO | disclosed |
| WO-2008116920-A2 | 17BETA-HYDROXYSTEROID-DEHYDROGENASE TYPE 1 INHIBITORS FOR THE TREATMENT OF HORMONE-DEPENDENT DISEASES | Universität des Saarlandes (DE) | 2008-10-02 | — | — | WO | disclosed |