Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | GLA | P06280 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 6/20 | 0.38 |
| ▸ | MAPT | P10636 | 6/20 | 0.38 |
| ▸ | NPC1 | O15118 | 3/20 | 0.38 |
| ▸ | HPGD | P15428 | 3/20 | 0.38 |
| ▸ | RAB9A | P51151 | 3/20 | 0.38 |
| ▸ | AR | P10275 | 1/20 | 0.38 |
| ▸ | ACHE | P22303 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | LPAR1 | Q92633 | 8/20 | 0.37 |
| ▸ | HTT | P42858 | 2/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.34 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4609623 | 0.85 | ALDH1A1 (0.49) | ALDH1A1GLAL3MBTL1ACHESMN1; SMN2 | |
| SCHEMBL4609577 | 0.85 | ALDH1A1 (0.49) | ALDH1A1GLAL3MBTL1ACHESMN1; SMN2 | |
| SCHEMBL4609570 | 0.85 | ALDH1A1 (0.49) | ALDH1A1GLAL3MBTL1ACHESMN1; SMN2 | |
| SCHEMBL13599411 | 0.85 | TTR (0.47) | ALDH1A1MAPTNPC1HPGDRAB9A | |
| SCHEMBL1556778 | 0.83 | MAPT (0.42) | ALDH1A1MAPTNPC1RAB9ACYP1A2 | |
| SCHEMBL1556773 | 0.83 | MAPT (0.42) | ALDH1A1MAPTNPC1RAB9ACYP1A2 | |
| SCHEMBL6741923 | 0.74 | ALDH1A1 (0.40) | ALDH1A1GLASMN1; SMN2CYP3A4KDM4E | |
| SCHEMBL17226995 | 0.74 | ALDH1A1 (0.40) | ALDH1A1GLASMN1; SMN2CYP3A4KDM4E | |
| SCHEMBL4610991 | 0.74 | ALDH1A1 (0.51) | ALDH1A1GLAMAPTHPGDCYP1A2 | |
| SCHEMBL4610998 | 0.74 | ALDH1A1 (0.51) | ALDH1A1GLAMAPTHPGDCYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120301552-A1 | CaSR Antagonist | JAPAN TOBACCO INC. (JP) | 2012-11-29 | — | — | US | disclosed |
| US-20080255042-A1 | CaSR Antagonist | JAPAN TOBACCO INC. (JP) | 2008-10-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120301552-A1 | CaSR Antagonist | CASR, CALCR, CALCRL | ALDH1A1 3748/4885GLA 2058/4885L3MBTL1 4402/4885 |
| US-20080255042-A1 | CaSR Antagonist | CASR, CALCR, CALCRL | ALDH1A1 3748/4885GLA 2058/4885L3MBTL1 4402/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.