Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.40 |
| ▸ | MAPT | P10636 | 4/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.40 |
| ▸ | POLB | P06746 | 2/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.40 |
| ▸ | CASP1 | P29466 | 2/20 | 0.40 |
| ▸ | KDM4A | O75164 | 1/20 | 0.40 |
| ▸ | KDM4B | O94953 | 1/20 | 0.40 |
| ▸ | KDM4D | Q6B0I6 | 1/20 | 0.40 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 5/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | USP2 | O75604 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 3/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.37 |
| ▸ | RECQL | P46063 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15359658 | 0.87 | SMN1; SMN2 (0.39) | KDM4EMAPTSMN1; SMN2HSD17B10ALDH1A1 | |
| SCHEMBL14942692 | 0.81 | USP2 (0.45) | KDM4EMAPTSMN1; SMN2HSD17B10ALDH1A1 | |
| SCHEMBL14029139 | 0.78 | KDM4E (0.39) | KDM4EMAPTSMN1; SMN2HSD17B10ALDH1A1 | |
| SCHEMBL13265663 | 0.74 | KMT2A (0.41) | KDM4EMAPTSMN1; SMN2HSD17B10ALDH1A1 | |
| SCHEMBL13240451 | 0.71 | KMT2A (0.40) | KDM4EMAPTSMN1; SMN2HSD17B10ALDH1A1 | |
| SCHEMBL12787467 | 0.70 | SMN1; SMN2 (0.41) | SMN1; SMN2L3MBTL1 | |
| SCHEMBL14123250 | 0.69 | SMN1; SMN2 (0.71) | MAPTSMN1; SMN2HSD17B10ALDH1A1L3MBTL1 | |
| SCHEMBL30595147 | 0.68 | KDM4E (0.41) | KDM4EMAPTSMN1; SMN2HSD17B10ALDH1A1 | |
| SCHEMBL12673026 | 0.68 | SMN1; SMN2 (0.42) | KDM4EMAPTSMN1; SMN2ALDH1A1L3MBTL1 | |
| SCHEMBL14906960 | 0.68 | MAPK1 (0.37) | KDM4EMAPTSMN1; SMN2HSD17B10ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080261953-A1 | Compounds, Compositions and Methods of Inhibiting Alpha-Synuclein Toxicity | WHITEHEAD INSTITUTE FOR BIOMEDICAL RESEARCH (US) | 2008-10-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080261953-A1 | Compounds, Compositions and Methods of Inhibiting Alpha-Synuclein Toxicity | SNCA, PARK7, HTT | KDM4E 1289/4885MAPT 30/4885SMN1; SMN2 41/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.