Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | STK4 | Q13043 | 12/20 | 0.70 |
| ▸ | STK3 | Q13188 | 2/20 | 0.53 |
| ▸ | EGFR | P00533 | 7/20 | 0.51 |
| ▸ | ERBB2 | P04626 | 2/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2543431 | 0.89 | STK4 (0.68) | STK4STK3EGFRERBB2 | |
| SCHEMBL30847382 | 0.89 | STK4 (0.68) | STK4STK3EGFRERBB2 | |
| SCHEMBL13928069 | 0.88 | STK4 (0.56) | STK4EGFRERBB2 | |
| SCHEMBL2610723 | 0.88 | STK4 (0.56) | STK4EGFRERBB2 | |
| SCHEMBL29514941 | 0.88 | STK4 (0.71) | STK4STK3EGFRERBB2 | |
| SCHEMBL2129771 | 0.88 | STK4 (0.71) | STK4STK3EGFRERBB2 | |
| SCHEMBL5255823 | 0.83 | STK4 (0.65) | STK4STK3EGFRERBB2 | |
| SCHEMBL22419663 | 0.83 | STK4 (1.00) | STK4STK3EGFRERBB2 | |
| SCHEMBL18343640 | 0.81 | STK4 (1.00) | STK4STK3EGFRERBB2 | |
| SCHEMBL4744821 | 0.81 | EGFR (0.55) | STK4EGFRERBB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7432377-B2 | Quinoline intermediates of receptor tyrosine kinase inhibitors and the synthesis thereof | WYETH (US) | 2008-10-07 | — | — | US | disclosed |
| US-7399865-B2 | such as (E)-N-{4-[4-(benzyloxy)-3-chloroanilino]-3-cyano-7-ethoxy-6-quinolinyl}-4-(dimethylamino)-2-butenamide used as antineoplastic agents, or inhibitors of the HER-2 gene or proteins and epidermal growth factor receptor enzymes | WYETH (US) | 2008-07-15 | — | — | US | disclosed |