Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TOP1 | P11387 | 3/20 | 0.40 |
| ▸ | TTR | P02766 | 1/20 | 0.39 |
| ▸ | CISD1 | Q9NZ45 | 8/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.32 |
| ▸ | HPGD | P15428 | 2/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.32 |
| ▸ | PIM1 | P11309 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3814338 | 0.90 | TOP1 (0.35) | TOP1CISD1ALDH1A1HPGDKDM4E | |
| SCHEMBL14048262 | 0.89 | TOP1 (0.49) | TOP1TTRALDH1A1HPGDKDM4E | |
| SCHEMBL3819336 | 0.88 | TOP1 (0.33) | TOP1CISD1ALDH1A1HPGDKDM4E | |
| SCHEMBL14048232 | 0.83 | TTR (0.40) | TOP1TTRALDH1A1HPGDKDM4E | |
| SCHEMBL3810694 | 0.82 | KDM4E (0.43) | TOP1ALDH1A1HPGDKDM4EHSD17B10 | |
| SCHEMBL3819773 | 0.81 | KDM4E (0.44) | TOP1ALDH1A1HPGDKDM4EHSD17B10 | |
| SCHEMBL3816061 | 0.80 | TOP1 (0.46) | TOP1ALDH1A1HPGDKDM4ETSHR | |
| SCHEMBL4908453 | 0.78 | KDM4E (0.42) | TOP1ALDH1A1HPGDKDM4EHSD17B10 | |
| SCHEMBL3814971 | 0.78 | TOP1 (0.43) | TOP1ALDH1A1HPGDKDM4ETSHR | |
| SCHEMBL4388089 | 0.77 | KDM4E (0.43) | TOP1ALDH1A1HPGDKDM4EHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080255060-A1 | Ester Linked Macrolides Useful For The Treatment of Microbial Infections | GLAXOSMITHKLINE ISTRAZIVACKI CENTER ZAGREB (HR) | 2008-10-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080255060-A1 | Ester Linked Macrolides Useful For The Treatment of Microbial Infections | CYP51A1, TLR5, MALT1 | TOP1 2305/4885TTR 2227/4885CISD1 3363/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.