Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 3/20 | 0.49 |
| ▸ | DRD4 | P21917 | 2/20 | 0.49 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.48 |
| ▸ | HTR1A | P08908 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | DRD2 | P14416 | 2/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | DRD3 | P35462 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 2/20 | 0.36 |
| ▸ | RAB9A | P51151 | 2/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13200659 | 0.92 | HTR2A (0.50) | HTR2ADRD4ADRA1AHTR1AMAPT | |
| SCHEMBL13200680 | 0.87 | HTR2A (0.54) | HTR2ADRD4ADRA1AHTR1AMAPT | |
| SCHEMBL13200681 | 0.86 | DRD4 (0.57) | HTR2ADRD4ADRA1AHTR1AMAPT | |
| SCHEMBL13200718 | 0.85 | ADRA1A (0.56) | HTR2ADRD4ADRA1AHTR1AMAPT | |
| SCHEMBL13200725 | 0.83 | DRD4 (0.51) | HTR2ADRD4ADRA1AHTR1AMAPT | |
| SCHEMBL13200678 | 0.82 | POLB (0.47) | HTR2ADRD4MAPTPOLBALDH1A1 | |
| SCHEMBL13200594 | 0.80 | HTR2A (0.48) | HTR2ADRD4ADRA1AHTR1AMAPT | |
| SCHEMBL13200733 | 0.80 | DRD4 (0.51) | HTR2ADRD4ADRA1AHTR1AMAPT | |
| SCHEMBL13200709 | 0.80 | DRD4 (0.56) | HTR2ADRD4ADRA1AHTR1AMAPT | |
| SCHEMBL13200674 | 0.79 | DRD4 (0.54) | HTR2ADRD4ADRA1AHTR1AMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1632483-B1 | HETEROCYCLIC SUBSTITUTED CARBONYL DERIVATIVES AND THEIR USE AS DOPAMINE D3 RECEPTOR LIGANDS | AVENTIS PHARMA INC (US) | 2008-10-29 | — | — | EP | disclosed |