Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC3 | O15379 | 2/20 | 0.79 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.79 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.79 |
| ▸ | HDAC10 | Q969S8 | 2/20 | 0.79 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.79 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.79 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.79 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.79 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.79 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.79 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.79 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.79 |
| ▸ | LMNA | P02545 | 7/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 4/20 | 0.49 |
| ▸ | HTT | P42858 | 2/20 | 0.49 |
| ▸ | GAA | P10253 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 2/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.48 |
| ▸ | HPGD | P15428 | 4/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13029067 | 0.92 | HDAC3 (0.82) | HDAC3HDAC1HDAC2HDAC10HDAC8 | |
| SCHEMBL14769055 | 0.90 | HDAC1 (0.84) | HDAC3HDAC1HDAC2HDAC10HDAC8 | |
| SCHEMBL13029066 | 0.89 | HDAC3 (0.84) | HDAC3HDAC1HDAC2HDAC10HDAC8 | |
| SCHEMBL14918260 | 0.89 | HDAC3 (0.77) | HDAC3HDAC1HDAC2HDAC10HDAC8 | |
| SCHEMBL443054 | 0.89 | HDAC3 (0.82) | HDAC3HDAC1HDAC2HDAC10HDAC8 | |
| SCHEMBL443345 | 0.89 | HDAC3 (0.82) | HDAC3HDAC1HDAC2HDAC10HDAC8 | |
| Abexinostat SCHEMBL444280 | 0.89 | HDAC6 (1.00) | HDAC3HDAC1HDAC2HDAC10HDAC8 | |
| Potassium Ion SCHEMBL443346 | 0.89 | HDAC3 (0.82) | HDAC3HDAC1HDAC2HDAC10HDAC8 | |
| Abexinostat SCHEMBL29489677 | 0.89 | HDAC6 (1.00) | HDAC3HDAC1HDAC2HDAC10HDAC8 | |
| SCHEMBL16621925 | 0.88 | HDAC3 (0.81) | HDAC3HDAC1HDAC2HDAC10HDAC8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008128093-A1 | CALCIUM FLUX AS A PHARMACOEFFICACY BIOMARKER FOR INHIBITORS OF HISTONE DEACETYLASE | PHARMACYCLICS, INC. (US) | 2008-10-23 | — | — | WO | disclosed |