Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 3/20 | 0.84 |
| ▸ | HDAC2 | Q92769 | 3/20 | 0.84 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.84 |
| ▸ | HDAC10 | Q969S8 | 2/20 | 0.84 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.84 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.84 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.84 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.84 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.84 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.84 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.84 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.84 |
| ▸ | LMNA | P02545 | 7/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 4/20 | 0.48 |
| ▸ | HTT | P42858 | 2/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 2/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Abexinostat SCHEMBL29489677 | 0.92 | HDAC6 (1.00) | HDAC1HDAC2HDAC3HDAC10HDAC8 | |
| Abexinostat SCHEMBL444280 | 0.92 | HDAC6 (1.00) | HDAC1HDAC2HDAC3HDAC10HDAC8 | |
| Abexinostat SCHEMBL29544306 | 0.91 | HDAC6 (1.00) | HDAC1HDAC2HDAC3HDAC10HDAC8 | |
| Abexinostat SCHEMBL14762281 | 0.91 | HDAC6 (1.00) | HDAC1HDAC2HDAC3HDAC10HDAC8 | |
| SCHEMBL14048655 | 0.90 | HDAC3 (0.79) | HDAC1HDAC2HDAC3HDAC10HDAC8 | |
| SCHEMBL4252161 | 0.89 | HDAC1 (0.84) | HDAC1HDAC2HDAC3HDAC10HDAC8 | |
| SCHEMBL13029066 | 0.89 | HDAC3 (0.84) | HDAC1HDAC2HDAC3HDAC10HDAC8 | |
| SCHEMBL443054 | 0.88 | HDAC3 (0.82) | HDAC1HDAC2HDAC3HDAC10HDAC8 | |
| Potassium Ion SCHEMBL443346 | 0.88 | HDAC3 (0.82) | HDAC1HDAC2HDAC3HDAC10HDAC8 | |
| SCHEMBL443345 | 0.88 | HDAC3 (0.82) | HDAC1HDAC2HDAC3HDAC10HDAC8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20170313671-A1 | NEW SALT OF ABEXINOSTAT, ASSOCIATED CRYSTALLINE FORM, A PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | PHARMACYCLICS, INC. | 2017-11-02 | — | — | US | disclosed |
| US-9421208-B2 | Methods for the treatment of solid tumors | PHARMACYCLICS LLC (US) | 2016-08-23 | — | — | US | disclosed |
| US-20150315167-A1 | NEW SALT OF ABEXINOSTAT, ASSOCIATED CRYSTALLINE FORM, A PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | PHARMACYCLICS, INC. | 2015-11-05 | — | — | US | disclosed |
| US-9115108-B2 | Salt of abexinostat, associated crystalline form, a process for their preparation and pharmaceutical compositions containing them | PHARMACYCLICS, INC. (US) | 2015-08-25 | — | — | US | disclosed |
| US-20150038513-A1 | ASSOCIATION BETWEEN N-HYDROXY-4-BENZAMIDE AND FOLFOX | PHARMACYCLICS LLC | 2015-02-05 | — | — | US | disclosed |
| US-20150038518-A1 | METHODS FOR THE TREATMENT OF SOLID TUMORS | PHARMACYCLICS LLC | 2015-02-05 | — | — | US | disclosed |
| US-20150024040-A1 | ADMINISTRATION REGIME FOR N-HYDROXY-4-BENZAMIDE | PHARMACYCLICS LLC | 2015-01-22 | — | — | US | disclosed |
| US-8883199-B2 | Administration regime for N-hydroxy-4-{2-[3-(N,N-dimethylaminomethyl)benzofuran-2- ylcarbonylamino]ethoxy}benzamide | LES LABORATOIRES SERVIER (FR) | 2014-11-11 | — | — | US | disclosed |
| US-20140249215-A1 | NEW SALT OF ABEXINOSTAT, ASSOCIATED CRYSTALLINE FORM, A PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | PHARMACYCLICS (US) | 2014-09-04 | — | — | US | disclosed |
| US-20130064880-A1 | ADMINISTRATION REGIME FOR N-HYDROXY-4-BENZAMIDE | PHARMACYCLICS, INC. | 2013-03-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150038518-A1 | METHODS FOR THE TREATMENT OF SOLID TUMORS | HDAC1, HDAC4, HDAC2 | HDAC1 1/4885HDAC2 3/4885HDAC3 4/4885 |
| US-20130064880-A1 | ADMINISTRATION REGIME FOR N-HYDROXY-4-BENZAMIDE | FOLR2, SLC19A1, FOLR1 | HDAC1 305/4885HDAC2 405/4885HDAC3 673/4885 |
| US-20150038513-A1 | ASSOCIATION BETWEEN N-HYDROXY-4-BENZAMIDE AND FOLFOX | FOLR2, FOLR1, SLC10A2 | HDAC1 344/4885HDAC2 349/4885HDAC3 394/4885 |
| US-20150315167-A1 | NEW SALT OF ABEXINOSTAT, ASSOCIATED CRYSTALLINE FORM, A PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | HAX1, REN, CANX | HDAC1 417/4885HDAC2 1779/4885HDAC3 885/4885 |
| US-20170313671-A1 | NEW SALT OF ABEXINOSTAT, ASSOCIATED CRYSTALLINE FORM, A PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | HAX1, REN, CANX | HDAC1 417/4885HDAC2 1779/4885HDAC3 885/4885 |
| US-20150024040-A1 | ADMINISTRATION REGIME FOR N-HYDROXY-4-BENZAMIDE | FOLR2, SLC19A1, FOLR1 | HDAC1 305/4885HDAC2 405/4885HDAC3 673/4885 |
| US-20140249215-A1 | NEW SALT OF ABEXINOSTAT, ASSOCIATED CRYSTALLINE FORM, A PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | HAX1, REN, CANX | HDAC1 417/4885HDAC2 1779/4885HDAC3 885/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.