Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCD | O00767 | 4/20 | 0.60 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.58 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.57 |
| ▸ | RECQL | P46063 | 1/20 | 0.57 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.57 |
| ▸ | MAPT | P10636 | 1/20 | 0.57 |
| ▸ | FSCN1 | Q16658 | 2/20 | 0.56 |
| ▸ | HTT | P42858 | 1/20 | 0.54 |
| ▸ | STAT3 | P40763 | 1/20 | 0.53 |
| ▸ | TP53 | P04637 | 1/20 | 0.53 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5532025 | 0.86 | RAB9A (0.65) | SCDSMN1; SMN2MAPK1RECQLMAPK10 | |
| SCHEMBL16210930 | 0.84 | SMN1; SMN2 (0.64) | SMN1; SMN2RECQLMAPK10HTTSTAT3 | |
| SCHEMBL29692294 | 0.84 | SMN1; SMN2 (0.64) | SMN1; SMN2RECQLMAPK10HTTSTAT3 | |
| SCHEMBL2315711 | 0.83 | SCD (0.63) | SCDSMN1; SMN2MAPK1FSCN1HTT | |
| SCHEMBL2317430 | 0.83 | SCD (0.63) | SCDSMN1; SMN2MAPK1FSCN1HTT | |
| SCHEMBL3087107 | 0.83 | SCD (0.63) | SCDSMN1; SMN2MAPK1FSCN1HTT | |
| SCHEMBL2312640 | 0.83 | SCD (0.63) | SCDSMN1; SMN2MAPK1FSCN1HTT | |
| SCHEMBL17677816 | 0.82 | GRK2 (0.64) | SMN1; SMN2RECQLMAPK10HTTSTAT3 | |
| SCHEMBL5529666 | 0.82 | SMN1; SMN2 (0.67) | SMN1; SMN2RECQLMAPK10MAPTHTT | |
| SCHEMBL2314932 | 0.80 | SCD (0.66) | SCDSMN1; SMN2MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1687284-B1 | p-38 KINASE INHIBITORS | NOVARTIS AG (CH) | 2008-10-29 | — | — | EP | disclosed |