Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRAF | P15056 | 16/20 | 0.36 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.34 |
| ▸ | F7 | P08709 | 1/20 | 0.34 |
| ▸ | GPR142 | Q7Z601 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1404811 | 0.92 | BRAF (0.38) | BRAFGPR142 | |
| SCHEMBL5779078 | 0.91 | BRAF (0.37) | BRAFGPR142 | |
| SCHEMBL1404576 | 0.90 | BRAF (0.39) | BRAF | |
| SCHEMBL1404842 | 0.89 | BRAF (0.40) | BRAFMAPK14 | |
| SCHEMBL1384412 | 0.89 | BRAF (0.37) | BRAFMAPK14F7GPR142 | |
| SCHEMBL1404608 | 0.89 | BRAF (0.35) | BRAFGPR142 | |
| SCHEMBL1404669 | 0.88 | BRAF (0.36) | BRAFGPR142 | |
| SCHEMBL1404647 | 0.88 | BRAF (0.36) | BRAF | |
| SCHEMBL1404662 | 0.88 | MAPK14 (0.38) | BRAFMAPK14 | |
| SCHEMBL1404768 | 0.87 | ABL1 (0.38) | BRAFGPR142 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1692116-B1 | 1,2,3-TRIAZOLE AMIDE DERIVATIVES AS INHIBITORS OF CYTOKINE PRODUCTION | BOEHRINGER INGELHEIM PHARMA (US) | 2011-03-09 | — | — | EP | claimed |