Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRAF | P15056 | 15/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | NR1I2 | O75469 | 3/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1404811 | 0.94 | BRAF (0.38) | BRAFNR1I2 | |
| SCHEMBL5779078 | 0.92 | BRAF (0.37) | BRAFNR1I2 | |
| SCHEMBL1404902 | 0.90 | BRAF (0.36) | BRAF | |
| SCHEMBL1404669 | 0.90 | BRAF (0.36) | BRAF | |
| SCHEMBL1404662 | 0.90 | MAPK14 (0.38) | BRAF | |
| SCHEMBL1404647 | 0.90 | BRAF (0.36) | BRAF | |
| SCHEMBL1404758 | 0.89 | BRAF (0.37) | BRAF | |
| SCHEMBL1404961 | 0.89 | BRAF (0.36) | BRAF | |
| SCHEMBL1404725 | 0.88 | BRAF (0.38) | BRAF | |
| SCHEMBL1380031 | 0.88 | TUBB4A (0.41) | BRAFTP53MAPTSMN1; SMN2NR1I2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1692116-B1 | 1,2,3-TRIAZOLE AMIDE DERIVATIVES AS INHIBITORS OF CYTOKINE PRODUCTION | BOEHRINGER INGELHEIM PHARMA (US) | 2011-03-09 | — | — | EP | claimed |