Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DYRK1A | Q13627 | 12/20 | 0.79 |
| ▸ | DYRK1B | Q9Y463 | 10/20 | 0.79 |
| ▸ | DYRK2 | Q92630 | 9/20 | 0.79 |
| ▸ | CLK1 | P49759 | 8/20 | 0.79 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.71 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.71 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.71 |
| ▸ | AXL | P30530 | 1/20 | 0.57 |
| ▸ | CDK8 | P49336 | 1/20 | 0.57 |
| ▸ | TNIK | Q9UKE5 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3770371 | 0.89 | DYRK1A (1.00) | DYRK1ADYRK1BDYRK2CLK1AXL | |
| SCHEMBL8313435 | 0.86 | MAPK8 (0.71) | DYRK1ADYRK1BDYRK2CLK1MAPK8 | |
| SCHEMBL8320085 | 0.85 | AXL (0.76) | DYRK1ADYRK1BDYRK2CLK1MAPK8 | |
| SCHEMBL3351160 | 0.84 | MAPK8 (0.56) | DYRK1ADYRK1BDYRK2CLK1MAPK8 | |
| SCHEMBL8313442 | 0.84 | KIT (0.72) | DYRK1AMAPK8MAPK9MAPK10 | |
| SCHEMBL8317528 | 0.84 | SGK1 (0.74) | DYRK1ADYRK1BDYRK2CLK1MAPK8 | |
| SCHEMBL8320560 | 0.84 | MAP3K11 (0.69) | DYRK1ADYRK1BDYRK2CLK1MAPK8 | |
| SCHEMBL15833892 | 0.83 | DYRK1A (0.89) | DYRK1ADYRK1BDYRK2CLK1AXL | |
| SCHEMBL3771174 | 0.83 | DYRK1A (0.89) | DYRK1ADYRK1BDYRK2CLK1AXL | |
| SCHEMBL8320088 | 0.83 | KIT (0.68) | DYRK1ADYRK1BDYRK2CLK1MAPK8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7432375-B2 | JNK inhibitors | EISAI R & D MANAGEMENT CO., LTD. (JP) | 2008-10-07 | — | — | US | disclosed |