Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACVR1 | Q04771 | 2/20 | 0.37 |
| ▸ | POLB | P06746 | 2/20 | 0.36 |
| ▸ | AKR1C3 | P42330 | 2/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | MET | P08581 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.35 |
| ▸ | CNR2 | P34972 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 2/20 | 0.33 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.33 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.33 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.33 |
| ▸ | PRKDC | P78527 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | RECQL | P46063 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13745998 | 0.83 | BRD4 (0.45) | ACVR1POLBL3MBTL1METMAPT | |
| SCHEMBL18891808 | 0.83 | ACVR1 (0.37) | ACVR1POLBAKR1C3L3MBTL1MET | |
| SCHEMBL22403202 | 0.79 | ACVR1 (0.37) | ACVR1POLBMETMAPTALDH1A1 | |
| SCHEMBL25970829 | 0.79 | BRD4 (0.42) | ACVR1POLBL3MBTL1METMAPT | |
| SCHEMBL13753992 | 0.75 | KDR (0.53) | ACVR1METLRRK2KDRACVR1B | |
| SCHEMBL1488055 | 0.74 | BRD4 (0.54) | ACVR1L3MBTL1ALDH1A1SMN1; SMN2PIK3CA | |
| SCHEMBL18891807 | 0.73 | BRD4 (0.48) | L3MBTL1METMAPTALDH1A1SMN1; SMN2 | |
| SCHEMBL13745644 | 0.71 | ACVR1 (0.38) | ACVR1AKR1C3L3MBTL1MAPTALDH1A1 | |
| SCHEMBL1487564 | 0.70 | MAP4K1 (0.47) | METLRRK2PIK3CDPIK3CAPIK3CB | |
| SCHEMBL20503865 | 0.70 | BRD4 (0.45) | ACVR1L3MBTL1METMAPTALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7432375-B2 | JNK inhibitors | EISAI R & D MANAGEMENT CO., LTD. (JP) | 2008-10-07 | — | — | US | disclosed |