Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACVR1 | Q04771 | 4/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.35 |
| ▸ | BRD4 | O60885 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 2/20 | 0.34 |
| ▸ | PLK4 | O00444 | 1/20 | 0.33 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.33 |
| ▸ | ACVR1B | P36896 | 2/20 | 0.33 |
| ▸ | TGFBR1 | P36897 | 2/20 | 0.33 |
| ▸ | BMPR1B | O00238 | 1/20 | 0.33 |
| ▸ | BMPR1A | P36894 | 1/20 | 0.33 |
| ▸ | KDR | P35968 | 1/20 | 0.32 |
| ▸ | TGFBR2 | P37173 | 1/20 | 0.32 |
| ▸ | BMPR2 | Q13873 | 1/20 | 0.32 |
| ▸ | PRKAB1 | Q9Y478 | 1/20 | 0.32 |
| ▸ | PRKDC | P78527 | 1/20 | 0.32 |
| ▸ | CETP | P11597 | 1/20 | 0.32 |
| ▸ | TP53 | P04637 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13745646 | 0.82 | ACVR1 (0.46) | ACVR1LRRK2ACVR1BTGFBR1BMPR1B | |
| SCHEMBL13745883 | 0.79 | ACVR1 (0.36) | ACVR1ALDH1A1SMN1; SMN2LRRK2BRD4 | |
| SCHEMBL13745827 | 0.75 | PTGER4 (0.38) | — | |
| SCHEMBL1488055 | 0.72 | BRD4 (0.54) | ACVR1ALDH1A1SMN1; SMN2BRD4L3MBTL1 | |
| SCHEMBL18891808 | 0.71 | ACVR1 (0.37) | ACVR1ALDH1A1SMN1; SMN2LMNALRRK2 | |
| SCHEMBL14049302 | 0.71 | ACVR1 (0.37) | ACVR1ALDH1A1SMN1; SMN2LMNALRRK2 | |
| SCHEMBL13745998 | 0.71 | BRD4 (0.45) | ACVR1ALDH1A1SMN1; SMN2LMNABRD4 | |
| SCHEMBL13745928 | 0.71 | CAMKK2 (0.41) | BRD4 | |
| SCHEMBL25970829 | 0.68 | BRD4 (0.42) | ACVR1ALDH1A1SMN1; SMN2LMNALRRK2 | |
| SCHEMBL22403202 | 0.68 | ACVR1 (0.37) | ACVR1ALDH1A1SMN1; SMN2LRRK2ACVR1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090215771-A1 | JNK INHIBITORS | GRACZYK PIOTR | 2009-08-27 | — | — | US | disclosed |
| US-7432375-B2 | JNK inhibitors | EISAI R & D MANAGEMENT CO., LTD. (JP) | 2008-10-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090215771-A1 | JNK INHIBITORS | MAPKAPK2, MAPK1, MAPKAPK3 | ACVR1 4781/4885ALDH1A1 3681/4885SMN1; SMN2 576/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.