Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 10/20 | 0.66 |
| ▸ | MEN1 | O00255 | 6/20 | 0.66 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.66 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.60 |
| ▸ | HTT | P42858 | 2/20 | 0.60 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.60 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.59 |
| ▸ | PIK3CD | O00329 | 5/20 | 0.58 |
| ▸ | PIK3CG | P48736 | 4/20 | 0.58 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.58 |
| ▸ | PIK3CB | P42338 | 2/20 | 0.58 |
| ▸ | PRKDC | P78527 | 1/20 | 0.56 |
| ▸ | PIK3C3 | Q8NEB9 | 1/20 | 0.56 |
| ▸ | POLB | P06746 | 1/20 | 0.55 |
| ▸ | GFER | P55789 | 1/20 | 0.55 |
| ▸ | TNF | P01375 | 1/20 | 0.54 |
| ▸ | LMNA | P02545 | 1/20 | 0.54 |
| ▸ | NOD2 | Q9HC29 | 1/20 | 0.54 |
| ▸ | NOD1 | Q9Y239 | 1/20 | 0.54 |
| ▸ | TP53 | P04637 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL188925 | 0.92 | PIK3CD (0.70) | MAPTMEN1KMT2AKDM4EHTT | |
| SCHEMBL12292204 | 0.89 | MAPT (0.62) | MAPTMEN1KMT2AKDM4EHTT | |
| SCHEMBL14050652 | 0.89 | MEN1 (0.62) | MAPTMEN1KMT2AKDM4EHTT | |
| SCHEMBL14050635 | 0.87 | PIK3CD (0.72) | MAPTMEN1KMT2APIK3CDPIK3CG | |
| SCHEMBL15095961 | 0.87 | MAPT (0.67) | MAPTMEN1KMT2AKDM4EHTT | |
| SCHEMBL3137612 | 0.86 | MAPT (0.79) | MAPTMEN1KMT2AKDM4EHTT | |
| SCHEMBL14050666 | 0.86 | MAPT (0.56) | MAPTMEN1KMT2AKDM4EHTT | |
| SCHEMBL10198904 | 0.86 | MAPT (0.56) | MAPTMEN1KMT2AKDM4EHTT | |
| SCHEMBL15256361 | 0.86 | MEN1 (0.64) | MAPTMEN1KMT2AKDM4EHTT | |
| SCHEMBL6992427 | 0.86 | MEN1 (0.65) | MAPTMEN1KMT2AKDM4EHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008127594-A2 | COMBINATION THERAPIES COMPRISING QUINOXALINE INHIBITORS OF PI3K-ALPHA FOR USE IN THE TREATMENT OF CANCER | EXELIXIS, INC. (US) | 2008-10-23 | — | — | WO | disclosed |