Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 9/20 | 0.62 |
| ▸ | KMT2A | Q03164 | 9/20 | 0.62 |
| ▸ | MAPT | P10636 | 11/20 | 0.61 |
| ▸ | POLB | P06746 | 2/20 | 0.61 |
| ▸ | GFER | P55789 | 1/20 | 0.61 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.60 |
| ▸ | GAA | P10253 | 4/20 | 0.60 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.60 |
| ▸ | HTT | P42858 | 3/20 | 0.60 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.60 |
| ▸ | LMNA | P02545 | 2/20 | 0.60 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.60 |
| ▸ | HPGD | P15428 | 1/20 | 0.60 |
| ▸ | RECQL | P46063 | 1/20 | 0.60 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.59 |
| ▸ | CTNNB1 | P35222 | 1/20 | 0.58 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.56 |
| ▸ | CDC25A | P30304 | 1/20 | 0.56 |
| ▸ | CDC25B | P30305 | 1/20 | 0.56 |
| ▸ | EGFR | P00533 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12292204 | 0.97 | MAPT (0.62) | MEN1KMT2AMAPTPOLBGFER | |
| SCHEMBL14050666 | 0.92 | MAPT (0.56) | MEN1KMT2AMAPTPOLBGFER | |
| SCHEMBL10198904 | 0.92 | MAPT (0.56) | MEN1KMT2AMAPTPOLBGFER | |
| SCHEMBL15256361 | 0.92 | MEN1 (0.64) | MEN1KMT2AMAPTPOLBGFER | |
| SCHEMBL14050721 | 0.90 | MEN1 (0.79) | MEN1KMT2AMAPTPOLBGFER | |
| SCHEMBL12292974 | 0.89 | MEN1 (0.72) | MEN1KMT2AMAPTPOLBGFER | |
| SCHEMBL6992427 | 0.89 | MEN1 (0.65) | MEN1KMT2AMAPTPOLBGFER | |
| SCHEMBL14050580 | 0.89 | MAPT (0.66) | MEN1KMT2AMAPTPOLBGFER | |
| SCHEMBL15256408 | 0.88 | MAPT (0.73) | MEN1KMT2AMAPTPOLBGFER | |
| SCHEMBL14050632 | 0.87 | MAPT (0.73) | MEN1KMT2AMAPTPOLBGFER |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008127594-A2 | COMBINATION THERAPIES COMPRISING QUINOXALINE INHIBITORS OF PI3K-ALPHA FOR USE IN THE TREATMENT OF CANCER | EXELIXIS, INC. (US) | 2008-10-23 | — | — | WO | disclosed |
| WO-2008021389-A2 | USING PI3K AND MEK MODULATORS IN TREATMENTS OF CANCER | EXELIXIS, INC. (US) | 2008-02-21 | — | — | WO | disclosed |