Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 3/20 | 0.54 |
| ▸ | CDK2 | P24941 | 7/20 | 0.52 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.46 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.46 |
| ▸ | VCP | P55072 | 2/20 | 0.44 |
| ▸ | NAMPT | P43490 | 1/20 | 0.40 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.39 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.39 |
| ▸ | CDK1 | P06493 | 1/20 | 0.39 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.39 |
| ▸ | CDK7 | P50613 | 1/20 | 0.39 |
| ▸ | CCNH | P51946 | 1/20 | 0.39 |
| ▸ | MNAT1 | P51948 | 1/20 | 0.39 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.38 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.38 |
| ▸ | GPR39 | O43194 | 1/20 | 0.38 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.38 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12954287 | 0.90 | GSK3B (0.68) | GSK3BCDK2CCNA2CCNA1VCP | |
| SCHEMBL13304914 | 0.90 | GSK3B (0.54) | GSK3BCDK2CCNA2CCNA1VCP | |
| SCHEMBL14050764 | 0.88 | GSK3B (0.53) | GSK3BCDK2CCNA2CCNA1NAMPT | |
| SCHEMBL12954300 | 0.88 | GSK3B (0.53) | GSK3BCDK2CCNA2CCNA1NAMPT | |
| SCHEMBL13305326 | 0.87 | GSK3B (0.56) | GSK3BCDK2CCNA2CCNA1CCNE1 | |
| SCHEMBL12953665 | 0.86 | GSK3B (0.63) | GSK3BCDK2CCNA2CCNA1CCNE1 | |
| SCHEMBL12953517 | 0.86 | GSK3B (0.54) | GSK3BCDK2CCNA2CCNA1CCNE1 | |
| SCHEMBL13305401 | 0.86 | GSK3B (0.56) | GSK3BCDK2CCNA2CCNA1CCNE1 | |
| SCHEMBL14050780 | 0.85 | GSK3B (0.60) | GSK3BCDK2CCNA2CCNA1CCNE1 | |
| SCHEMBL14050761 | 0.85 | GSK3B (0.55) | GSK3BCDK2CCNA2CCNA1NAMPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008130569-A1 | NOVEL PYRAZOLOPYRIMIDINES AS CYCLIN DEPENDENT KINASE INHIBITORS | SCHERING CORPORATION (US) | 2008-10-30 | — | — | WO | disclosed |