Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 3/20 | 0.53 |
| ▸ | CDK2 | P24941 | 6/20 | 0.51 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.45 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.45 |
| ▸ | NAMPT | P43490 | 2/20 | 0.41 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.40 |
| ▸ | CTNNB1 | P35222 | 1/20 | 0.39 |
| ▸ | TCF7L2 | Q9NQB0 | 1/20 | 0.39 |
| ▸ | MAPK11 | Q15759 | 2/20 | 0.39 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.39 |
| ▸ | HPGDS | O60760 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14050764 | 0.98 | GSK3B (0.53) | GSK3BCDK2CCNA2CCNA1NAMPT | |
| SCHEMBL12953016 | 0.90 | GSK3B (0.67) | GSK3BCDK2CCNA2CCNA1 | |
| SCHEMBL12953764 | 0.89 | GSK3B (0.67) | GSK3BCDK2CCNA2CCNA1 | |
| SCHEMBL14050762 | 0.88 | GSK3B (0.54) | GSK3BCDK2CCNA2CCNA1NAMPT | |
| SCHEMBL12953507 | 0.87 | GSK3B (0.69) | GSK3BCDK2CCNA2CCNA1 | |
| SCHEMBL13305398 | 0.87 | GSK3B (0.54) | GSK3BCDK2CCNA2CCNA1MAPK11 | |
| SCHEMBL13305326 | 0.87 | GSK3B (0.56) | GSK3BCDK2CCNA2CCNA1HDAC1 | |
| SCHEMBL14043293 | 0.86 | GSK3B (0.49) | GSK3BCDK2CCNA2CCNA1 | |
| SCHEMBL14050761 | 0.86 | GSK3B (0.55) | GSK3BCDK2CCNA2CCNA1NAMPT | |
| SCHEMBL12953665 | 0.85 | GSK3B (0.63) | GSK3BCDK2CCNA2CCNA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1720882-B1 | PYRAZOLOPYRIMIDINE-DERIVATIVES AS CYCLIN DEPENDENT KINASE INHIBITORS | SCHERING CORP (US) | 2011-01-05 | — | — | EP | disclosed |
| WO-2008130570-A1 | NOVEL PYRAZOLOPYRIMIDINES AS CYCLIN DEPENDENT KINASE INHIBITORS | SCHERING CORPORATION (US) | 2008-10-30 | — | — | WO | disclosed |