Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 6/20 | 0.43 |
| ▸ | GSTO1 | P78417 | 1/20 | 0.40 |
| ▸ | CCNE1 | P24864 | 3/20 | 0.40 |
| ▸ | CDK2 | P24941 | 3/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | HPGD | P15428 | 2/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | CASP1 | P29466 | 1/20 | 0.38 |
| ▸ | CASP7 | P55210 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 3/20 | 0.38 |
| ▸ | MAPT | P10636 | 5/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 2/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12953087 | 0.91 | GSK3B (0.43) | GSK3BGSTO1CCNE1CDK2KDM4E | |
| SCHEMBL12954277 | 0.89 | GSK3B (0.42) | GSK3BGSTO1CCNE1CDK2KDM4E | |
| SCHEMBL12954264 | 0.88 | GSK3B (0.44) | GSK3BGSTO1CCNE1CDK2KDM4E | |
| SCHEMBL12954273 | 0.88 | GSK3B (0.49) | GSK3BGSTO1CCNE1CDK2KDM4E | |
| SCHEMBL12954174 | 0.88 | GSTO1 (0.43) | GSK3BGSTO1CCNE1CDK2KDM4E | |
| SCHEMBL13304916 | 0.87 | CYP3A4 (0.39) | KDM4EHPGDHSD17B10ALDH1A1LMNA | |
| SCHEMBL14413105 | 0.83 | CDK2 (0.48) | GSK3BCCNE1CDK2 | |
| SCHEMBL12953575 | 0.83 | CDK2 (0.48) | GSK3BCCNE1CDK2KDM4EHPGD | |
| SCHEMBL13118264 | 0.79 | CDK2 (0.42) | GSK3BCCNE1CDK2KDM4EHPGD | |
| SCHEMBL12954119 | 0.79 | CCNE1 (0.47) | CCNE1CDK2KDM4EALDH1A1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008130569-A1 | NOVEL PYRAZOLOPYRIMIDINES AS CYCLIN DEPENDENT KINASE INHIBITORS | SCHERING CORPORATION (US) | 2008-10-30 | — | — | WO | disclosed |
| US-7161003-B1 | Pyrazolopyrimidines as cyclin dependent kinase inhibitors | SCHERING CORPORATION (US) | 2007-01-09 | — | — | US | disclosed |