Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AURKA | O14965 | 4/20 | 0.41 |
| ▸ | PDPK1 | O15530 | 4/20 | 0.41 |
| ▸ | AURKB | Q96GD4 | 4/20 | 0.41 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.41 |
| ▸ | SUV39H2 | Q9H5I1 | 6/20 | 0.40 |
| ▸ | PDE10A | Q9Y233 | 3/20 | 0.40 |
| ▸ | BTK | Q06187 | 2/20 | 0.39 |
| ▸ | JAK3 | P52333 | 1/20 | 0.39 |
| ▸ | CKS1B | P61024 | 1/20 | 0.38 |
| ▸ | SKP1 | P63208 | 1/20 | 0.38 |
| ▸ | SKP2 | Q13309 | 1/20 | 0.38 |
| ▸ | EIF2AK4 | Q9P2K8 | 1/20 | 0.36 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.36 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.36 |
| ▸ | CDK2 | P24941 | 1/20 | 0.36 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14050863 | 0.92 | SUV39H2 (0.49) | AURKAPDPK1AURKBMAP4K4SUV39H2 | |
| SCHEMBL14413680 | 0.87 | PDE10A (0.41) | AURKAPDPK1AURKBMAP4K4SUV39H2 | |
| SCHEMBL14050954 | 0.83 | SUV39H2 (0.44) | AURKAPDPK1AURKBMAP4K4SUV39H2 | |
| SCHEMBL14051004 | 0.82 | PIM1 (0.43) | BTKCKS1BSKP1SKP2CHEK1 | |
| SCHEMBL14051006 | 0.82 | PIM1 (0.43) | BTKCKS1BSKP1SKP2CHEK1 | |
| SCHEMBL14050800 | 0.80 | PDE10A (0.47) | AURKAPDPK1AURKBMAP4K4SUV39H2 | |
| SCHEMBL14050999 | 0.80 | SUV39H2 (0.48) | MAP4K4SUV39H2PDE10ABTKJAK3 | |
| SCHEMBL14413671 | 0.80 | SUV39H2 (0.48) | MAP4K4SUV39H2PDE10ABTKJAK3 | |
| SCHEMBL14413640 | 0.78 | BTK (0.44) | AURKAPDPK1AURKBMAP4K4SUV39H2 | |
| SCHEMBL14413674 | 0.78 | CKS1B (0.51) | SUV39H2PDE10ABTKJAK3CKS1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008130569-A1 | NOVEL PYRAZOLOPYRIMIDINES AS CYCLIN DEPENDENT KINASE INHIBITORS | SCHERING CORPORATION (US) | 2008-10-30 | — | — | WO | disclosed |