Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIM1 | P11309 | 1/20 | 0.43 |
| ▸ | TYK2 | P29597 | 1/20 | 0.43 |
| ▸ | CDK2 | P24941 | 6/20 | 0.41 |
| ▸ | GSK3B | P49841 | 3/20 | 0.41 |
| ▸ | RET | P07949 | 2/20 | 0.40 |
| ▸ | CHEK1 | O14757 | 2/20 | 0.40 |
| ▸ | CCNA2 | P20248 | 2/20 | 0.40 |
| ▸ | CCNA1 | P78396 | 2/20 | 0.40 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.39 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.39 |
| ▸ | MERTK | Q12866 | 1/20 | 0.38 |
| ▸ | CKS1B | P61024 | 1/20 | 0.38 |
| ▸ | SKP1 | P63208 | 1/20 | 0.38 |
| ▸ | SKP2 | Q13309 | 1/20 | 0.38 |
| ▸ | JAK1 | P23458 | 2/20 | 0.38 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.38 |
| ▸ | MTOR | P42345 | 1/20 | 0.38 |
| ▸ | PRKDC | P78527 | 1/20 | 0.38 |
| ▸ | CSNK2B | P67870 | 1/20 | 0.38 |
| ▸ | JAK2 | O60674 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14051006 | 1.00 | PIM1 (0.43) | PIM1TYK2CDK2GSK3BRET | |
| SCHEMBL14413682 | 0.87 | CDK2 (0.45) | TYK2CDK2GSK3BRETMAPKAPK2 | |
| SCHEMBL14413684 | 0.87 | CDK2 (0.45) | TYK2CDK2GSK3BRETMAPKAPK2 | |
| SCHEMBL14051009 | 0.82 | AURKA (0.41) | CDK2CHEK1CCNA2CCNA1CKS1B | |
| SCHEMBL14050863 | 0.81 | SUV39H2 (0.49) | CKS1BSKP1SKP2BTK | |
| SCHEMBL11930830 | 0.78 | CDK2 (0.57) | PIM1CDK2GSK3BCHEK1CCNA2 | |
| SCHEMBL14543068 | 0.78 | CDK2 (0.57) | PIM1CDK2GSK3BCHEK1CCNA2 | |
| SCHEMBL11930829 | 0.78 | CDK2 (0.57) | PIM1CDK2GSK3BCHEK1CCNA2 | |
| SCHEMBL14413663 | 0.77 | GSK3B (0.42) | TYK2CDK2GSK3BMAPKAPK2CSNK2A1 | |
| SCHEMBL11930815 | 0.76 | CDK2 (0.47) | PIM1CDK2GSK3BRETCHEK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008130569-A1 | NOVEL PYRAZOLOPYRIMIDINES AS CYCLIN DEPENDENT KINASE INHIBITORS | SCHERING CORPORATION (US) | 2008-10-30 | — | — | WO | disclosed |