Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK2 | P24941 | 4/20 | 0.44 |
| ▸ | CHEK1 | O14757 | 2/20 | 0.44 |
| ▸ | CCNA2 | P20248 | 2/20 | 0.44 |
| ▸ | CCNA1 | P78396 | 2/20 | 0.44 |
| ▸ | POLB | P06746 | 3/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | NOS3 | P29474 | 1/20 | 0.35 |
| ▸ | NOS1 | P29475 | 1/20 | 0.35 |
| ▸ | NOS2 | P35228 | 1/20 | 0.35 |
| ▸ | PDE1B | Q01064 | 1/20 | 0.35 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.35 |
| ▸ | NSD2 | O96028 | 1/20 | 0.34 |
| ▸ | GSK3B | P49841 | 2/20 | 0.34 |
| ▸ | WNT1 | P04628 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11930869 | 0.79 | CHEK1 (0.61) | CDK2CHEK1CCNA2CCNA1GSK3B | |
| SCHEMBL11930815 | 0.77 | CDK2 (0.47) | CDK2CHEK1CCNA2CCNA1SMN1; SMN2 | |
| SCHEMBL11930825 | 0.69 | CDK2 (0.47) | CDK2CHEK1CCNA2CCNA1MEN1 | |
| SCHEMBL13845460 | 0.68 | CDK2 (0.50) | CDK2CHEK1CCNA2CCNA1KMT2A | |
| SCHEMBL11930818 | 0.68 | HRH4 (0.49) | CDK2CHEK1CCNA2CCNA1PIM1 | |
| SCHEMBL11930824 | 0.68 | HRH4 (0.49) | CDK2CHEK1CCNA2CCNA1PIM1 | |
| SCHEMBL14543100 | 0.67 | HRH4 (0.53) | — | |
| SCHEMBL15146127 | 0.67 | HRH4 (0.53) | — | |
| SCHEMBL12953557 | 0.66 | CHEK1 (0.73) | CDK2CHEK1CCNA2CCNA1GSK3B | |
| SCHEMBL11930827 | 0.66 | CDK2 (0.48) | CDK2CHEK1CCNA2CCNA1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008130569-A1 | NOVEL PYRAZOLOPYRIMIDINES AS CYCLIN DEPENDENT KINASE INHIBITORS | SCHERING CORPORATION (US) | 2008-10-30 | — | — | WO | disclosed |