Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK2 | O75116 | 11/20 | 0.45 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.43 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.40 |
| ▸ | JAK1 | P23458 | 1/20 | 0.39 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | TBK1 | Q9UHD2 | 1/20 | 0.35 |
| ▸ | MALT1 | Q9UDY8 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14050945 | 0.91 | PIK3CA (0.47) | ROCK2PIK3CAPIK3CDJAK1GPR119 | |
| SCHEMBL14418713 | 0.88 | IRAK1 (0.39) | PIK3CDGPR119 | |
| SCHEMBL14050984 | 0.84 | MALT1 (0.38) | PIK3CAGPR119HTTMALT1MEN1 | |
| SCHEMBL14051071 | 0.84 | ROCK2 (0.45) | ROCK2PIK3CAPIK3CDJAK1GPR119 | |
| SCHEMBL14050939 | 0.80 | CHEK1 (0.46) | ROCK2PIK3CAPIK3CDJAK1GPR119 | |
| SCHEMBL14051073 | 0.79 | CHEK1 (0.46) | PIK3CDGPR119MALT1 | |
| SCHEMBL14050795 | 0.78 | PIK3CA (0.51) | ROCK2PIK3CAPIK3CDJAK1GPR119 | |
| SCHEMBL13331859 | 0.76 | PIK3CA (0.51) | ROCK2PIK3CAPIK3CDJAK1GPR119 | |
| SCHEMBL14050794 | 0.75 | CHEK1 (0.45) | PIK3CAGPR119HTT | |
| SCHEMBL14050949 | 0.75 | PIK3CA (0.47) | ROCK2PIK3CAPIK3CDJAK1GPR119 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008130569-A1 | NOVEL PYRAZOLOPYRIMIDINES AS CYCLIN DEPENDENT KINASE INHIBITORS | SCHERING CORPORATION (US) | 2008-10-30 | — | — | WO | disclosed |