Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Tiotropium. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM3 known ✓ | P20309 | 17/20 | 1.00 |
| ▸ | CHRM2 | P08172 | 8/20 | 1.00 |
| ▸ | CHRM1 | P11229 | 6/20 | 1.00 |
| ▸ | CHRM4 | P08173 | 3/20 | 1.00 |
| ▸ | CHRM5 | P08912 | 3/20 | 1.00 |
| ▸ | TSPO | P30536 | 1/20 | 1.00 |
| ▸ | ADRA1A | P35348 | 1/20 | 1.00 |
| ▸ | HRH1 | P35367 | 1/20 | 1.00 |
| ▸ | OPRK1 | P41145 | 1/20 | 1.00 |
| ▸ | KCNH2 | Q12809 | 1/20 | 1.00 |
| ▸ | PDE3A | Q14432 | 1/20 | 1.00 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 1.00 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.48 |
| ▸ | BLM | P54132 | 2/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.45 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Tiotropium SCHEMBL155760 | 1.00 | CHRM3 (1.00) | CHRM3CHRM2CHRM1CHRM4CHRM5 | |
| Tiotropium SCHEMBL30426594 | 1.00 | CHRM3 (1.00) | CHRM3CHRM2CHRM1CHRM4CHRM5 | |
| Tiotropium SCHEMBL2399952 | 1.00 | CHRM3 (1.00) | CHRM3CHRM2CHRM1CHRM4CHRM5 | |
| Tiotropium SCHEMBL155761 | 0.99 | CHRM3 (0.98) | CHRM3CHRM2CHRM1CHRM4CHRM5 | |
| Tiotropium SCHEMBL14672487 | 0.99 | CHRM3 (1.00) | CHRM3CHRM2CHRM1CHRM4CHRM5 | |
| Tiotropium SCHEMBL19581677 | 0.99 | CHRM3 (1.00) | CHRM3CHRM2CHRM1CHRM4CHRM5 | |
| Tiotropium SCHEMBL4589 | 0.99 | CHRM3 (1.00) | CHRM3CHRM2CHRM1CHRM4CHRM5 | |
| Tiotropium SCHEMBL7607795 | 0.99 | CHRM3 (1.00) | CHRM3CHRM2CHRM1CHRM4CHRM5 | |
| Tiotropium SCHEMBL440873 | 0.99 | CHRM3 (1.00) | CHRM3CHRM2CHRM1CHRM4CHRM5 | |
| Tiotropium SCHEMBL15005742 | 0.99 | CHRM3 (1.00) | CHRM3CHRM2CHRM1CHRM4CHRM5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 60 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3922240-B1 | PHARMACEUTICAL COMPOSITION COMPRISING TIOTROPIUM BROMIDE | MEXICHEM FLUOR SA DE CV (MX) | 2023-06-21 | — | — | EP | claimed |
| EP-3515439-B1 | PHARMACEUTICAL COMPOSITION COMPRISING TIOTROPIUM BROMIDE | MEXICHEM FLUOR SA DE CV (MX) | 2021-12-15 | — | — | EP | claimed |
| EP-2007349-B1 | AEROSOL SUSPENSION FORMULATIONS COMPRISING TG 227 EA OR TG 134 A AS PROPELLANTS | BOEHRINGER INGELHEIM PHARMA (DE) | 2017-08-02 | — | — | EP | claimed |
| EP-2170270-B1 | COMPOSITIONS FOR DELIVERING MEDICAMENTS INTO THE LUNGS, USES THEREOF | PAKA PULMONARY PHARMACEUTICALS INC (US) | 2016-01-13 | — | — | EP | claimed |
| EP-2403851-B1 | NEW CRYSTALLINE FORMS OF TIOTROPIUM BROMIDE | BILGIC MAHMUT (TR) | 2015-06-17 | — | — | EP | claimed |
| EP-1695701-B1 | HFA suspension formulations comprising an anticholinergic agent | BOEHRINGER INGELHEIM PHARMA (DE) | 2015-01-07 | — | — | EP | claimed |
| EP-1496858-B1 | INHALATION KIT COMPRISUNG INHALABLE POWDER OF TIOTROPIUM | BOEHRINGER INGELHEIM PHARMA (DE) | 2013-08-14 | — | — | EP | claimed |
| EP-1789405-B1 | NOVEL ENANTIOMERICALLY PURE BETA-AGONISTS, METHOD FOR THE PRODUCTION AND THE USE THEREOF IN THE FORM OF A DRUG | BOEHRINGER INGELHEIM INT (DE) | 2013-07-17 | — | — | EP | claimed |
| EP-1827541-B1 | BLISTER FOR INHALERS | BOEHRINGER INGELHEIM INT (DE) | 2013-05-29 | — | — | EP | claimed |
| EP-1881980-B1 | NOVEL CRYSTALLINE FORMS OF TIOTROPIUM BROMIDE | BOEHRINGER INGELHEIM INT (DE) | 2012-08-22 | — | — | EP | claimed |
| EP-1610787-B1 | SYNERGISTIC COMBINATION COMPRISING ROFLUMILAST AND AN ANTICHOLINERGIC AGENT SELECTED FROM TIOTROPIUM SALTS FOR THE TREATMENT OF RESPIRATORY DISEASES | NYCOMED GMBH (DE) | 2008-01-23 | — | — | EP | claimed |
| EP-1333819-B1 | INHALATIVE SOLUTION FORMULATION CONTAINING A TIOTROPIUM SALT | BOEHRINGER INGELHEIM PHARMA (DE) | 2007-09-19 | — | — | EP | claimed |
| EP-1494648-B1 | POWDER FORMULATIONS SUITABLE FOR INHALATION | BOEHRINGER INGELHEIM PHARMA (DE) | 2006-09-20 | — | — | EP | claimed |
| EP-1401445-B1 | CRYSTALLINE ANTICHOLINERGIC, METHOD FOR ITS PRODUCTION, AND USE THEREOF IN THE PRODUCTION OF A DRUG | BOEHRINGER INGELHEIM PHARMA (DE) | 2006-08-23 | — | — | EP | claimed |
| CN-1237970-C | Inhalative solution formulation containing tiotropium salt | BOEHRINGER INGELHEIM PHARMA (DE) | 2006-01-25 | — | — | CN | claimed |
| CN-1473038-A | Inhalable formulations comprising tiotropium salt solutions | ���ָ��Ӣ��ķ�������Ϲ�˾ | 2004-02-04 | — | — | CN | claimed |
| CN-1473044-A | Inhalative solution formulation containing tiotropium salt | ���ָ��Ӣ��ķ�������Ϲ�˾ | 2004-02-04 | — | — | CN | claimed |
| CN-116018131-A | Fast orodispersible tablet with inner cavity | 阿普雷奇亚制药有限责任公司 | 2023-04-25 | — | — | CN | disclosed |
| CN-1473044-A | Inhalative solution formulation containing tiotropium salt | ���ָ��Ӣ��ķ�������Ϲ�˾ | 2004-02-04 | — | — | CN | disclosed |
| US-20020151541-A1 | For treatment of respiratory tract diseases | BOEHRINGER INGELHEIM PHARMA KG (DE) | 2002-10-17 | — | — | US | disclosed |