Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LRRK2 | Q5S007 | 18/20 | 0.52 |
| ▸ | BRD4 | O60885 | 2/20 | 0.38 |
| ▸ | PDGFRA | P16234 | 2/20 | 0.36 |
| ▸ | CSF1R | P07333 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14059307 | 0.87 | LRRK2 (0.66) | LRRK2PDGFRACSF1R | |
| SCHEMBL14059572 | 0.86 | LRRK2 (0.49) | LRRK2 | |
| SCHEMBL14059477 | 0.86 | LRRK2 (0.46) | LRRK2 | |
| SCHEMBL14059133 | 0.84 | LRRK2 (0.55) | LRRK2PDGFRACSF1R | |
| SCHEMBL14059961 | 0.84 | LRRK2 (0.70) | LRRK2PDGFRACSF1R | |
| SCHEMBL14062308 | 0.83 | LRRK2 (0.55) | LRRK2 | |
| SCHEMBL17135860 | 0.82 | LRRK2 (0.76) | LRRK2PDGFRACSF1R | |
| SCHEMBL17135861 | 0.82 | LRRK2 (0.76) | LRRK2PDGFRACSF1R | |
| SCHEMBL14059413 | 0.82 | LRRK2 (0.46) | LRRK2 | |
| SCHEMBL14059700 | 0.82 | LRRK2 (0.49) | LRRK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2726465-A1 | INHIBITORS OF LRRK2 KINASE ACTIVITY | Elan Pharmaceuticals Inc. (US) | 2014-05-07 | — | — | EP | claimed |
| WO-2012162254-A1 | INHIBITORS OF LRRK2 KINASE ACTIVITY | ELAN PHARMACEUTICALS, INC. (US) | 2012-11-29 | — | — | WO | claimed |
| EP-2726465-A1 | INHIBITORS OF LRRK2 KINASE ACTIVITY | Elan Pharmaceuticals Inc. (US) | 2014-05-07 | — | — | EP | disclosed |
| WO-2012162254-A1 | INHIBITORS OF LRRK2 KINASE ACTIVITY | ELAN PHARMACEUTICALS, INC. (US) | 2012-11-29 | — | — | WO | disclosed |