Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LRRK2 | Q5S007 | 6/20 | 0.46 |
| ▸ | PGR | P06401 | 1/20 | 0.40 |
| ▸ | AR | P10275 | 1/20 | 0.40 |
| ▸ | DHFR | P00374 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 8/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 7/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 7/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 7/20 | 0.39 |
| ▸ | TSHR | P16473 | 7/20 | 0.39 |
| ▸ | CLK4 | Q9HAZ1 | 7/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 6/20 | 0.39 |
| ▸ | LMNA | P02545 | 5/20 | 0.39 |
| ▸ | USP2 | O75604 | 5/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.37 |
| ▸ | HIF1A | Q16665 | 3/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.37 |
| ▸ | HPGD | P15428 | 3/20 | 0.37 |
| ▸ | GAA | P10253 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14059572 | 0.89 | LRRK2 (0.49) | LRRK2 | |
| SCHEMBL14059793 | 0.89 | LRRK2 (0.48) | LRRK2 | |
| SCHEMBL14059413 | 0.88 | LRRK2 (0.46) | LRRK2 | |
| SCHEMBL14059154 | 0.88 | LRRK2 (0.49) | LRRK2ALDH1A1HSD17B10CYP1A2CYP3A4 | |
| SCHEMBL14059532 | 0.86 | LRRK2 (0.44) | LRRK2ARALDH1A1CYP1A2CYP3A4 | |
| SCHEMBL14059347 | 0.86 | LRRK2 (0.52) | LRRK2 | |
| SCHEMBL14059769 | 0.85 | LRRK2 (0.46) | LRRK2 | |
| SCHEMBL14059700 | 0.84 | LRRK2 (0.49) | LRRK2 | |
| SCHEMBL14062308 | 0.84 | LRRK2 (0.55) | LRRK2 | |
| SCHEMBL14059211 | 0.83 | LRRK2 (0.52) | LRRK2ALDH1A1HSD17B10USP2MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2726465-A1 | INHIBITORS OF LRRK2 KINASE ACTIVITY | Elan Pharmaceuticals Inc. (US) | 2014-05-07 | — | — | EP | claimed |
| WO-2012162254-A1 | INHIBITORS OF LRRK2 KINASE ACTIVITY | ELAN PHARMACEUTICALS, INC. (US) | 2012-11-29 | — | — | WO | claimed |
| EP-2726465-A1 | INHIBITORS OF LRRK2 KINASE ACTIVITY | Elan Pharmaceuticals Inc. (US) | 2014-05-07 | — | — | EP | disclosed |
| WO-2012162254-A1 | INHIBITORS OF LRRK2 KINASE ACTIVITY | ELAN PHARMACEUTICALS, INC. (US) | 2012-11-29 | — | — | WO | disclosed |