Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TBK1 | Q9UHD2 | 19/20 | 1.00 |
| ▸ | IKBKE | Q14164 | 17/20 | 1.00 |
| ▸ | PRKCI | P41743 | 1/20 | 0.71 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14059588 | 0.89 | TBK1 (0.80) | TBK1IKBKEPRKCI | |
| SCHEMBL14059258 | 0.88 | TBK1 (0.80) | TBK1IKBKEPRKCI | |
| SCHEMBL14061575 | 0.87 | TBK1 (0.82) | TBK1IKBKEPRKCI | |
| SCHEMBL14059865 | 0.87 | TBK1 (1.00) | TBK1IKBKEPRKCI | |
| SCHEMBL14061479 | 0.86 | PRKCI (0.81) | TBK1IKBKEPRKCI | |
| SCHEMBL14059119 | 0.85 | TBK1 (0.74) | TBK1IKBKEPRKCI | |
| SCHEMBL14059115 | 0.85 | TBK1 (0.74) | TBK1IKBKEPRKCI | |
| SCHEMBL14061657 | 0.84 | PRKCI (0.79) | TBK1IKBKEPRKCI | |
| SCHEMBL14059524 | 0.84 | TBK1 (0.71) | TBK1IKBKEPRKCI | |
| SCHEMBL14059120 | 0.84 | TBK1 (0.71) | TBK1IKBKEPRKCI |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2714677-B1 | PYRIDINE-AND PYRAZINE DERIVATIVES | MERCK PATENT GMBH (DE) | 2018-08-22 | — | — | EP | claimed |
| WO-2012161877-A1 | PYRIDINE-AND PYRAZINE DERIVATIVES | MERCK PATENT GMBH (DE) | 2012-11-29 | — | — | WO | claimed |
| EP-2714677-B1 | PYRIDINE-AND PYRAZINE DERIVATIVES | MERCK PATENT GMBH (DE) | 2018-08-22 | — | — | EP | disclosed |
| US-9273029-B2 | Pyridine-and pyrazine derivatives | MERCK PATENT GMBH (DE) | 2016-03-01 | — | — | US | disclosed |
| US-9273029-B2 | Pyridine-and pyrazine derivatives | MERCK PATENT GMBH (DE) | 2016-03-01 | — | — | US | disclosed |
| US-9273029-B2 | Pyridine-and pyrazine derivatives | MERCK PATENT GMBH (DE) | 2016-03-01 | — | — | US | disclosed |
| US-20140142097-A1 | PYRIDINE-AND PYRAZINE DERIVATIVES | MERCK PATENT GMBH (DE) | 2014-05-22 | — | — | US | disclosed |
| US-20140142097-A1 | PYRIDINE-AND PYRAZINE DERIVATIVES | MERCK PATENT GMBH (DE) | 2014-05-22 | — | — | US | disclosed |
| US-20140142097-A1 | PYRIDINE-AND PYRAZINE DERIVATIVES | MERCK PATENT GMBH (DE) | 2014-05-22 | — | — | US | disclosed |
| WO-2012161877-A1 | PYRIDINE-AND PYRAZINE DERIVATIVES | MERCK PATENT GMBH (DE) | 2012-11-29 | — | — | WO | disclosed |
| WO-2012161877-A1 | PYRIDINE-AND PYRAZINE DERIVATIVES | MERCK PATENT GMBH (DE) | 2012-11-29 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140142097-A1 | PYRIDINE-AND PYRAZINE DERIVATIVES | TBK1, IRAK1, IRAK2 | TBK1 1/4885IKBKE 11/4885PRKCI 45/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.